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Invitrogen
ZC3H8 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-101962
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ZC3H8(Accession Q8N5P1), corresponding to amino acid residues D88-N138.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total ZC3H8.
靶标信息
Zinc-finger CCCH domain-containing protein 8 (ZC3H8) acts as a transcriptional repressor of the GATA3 promoter. It is a sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene. ZC3H8 induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: fetal liver zinc finger 1; fetal liver zinc finger 1; putative zinc finger protein FLIZ1; Fetal liver zinc finger protein 1; Zinc finger CCCH domain-containing protein 8; zinc finger CCCH type domain containing 8
基因别名: AU020882; E130108N08Rik; Fliz1; ZC3H8; ZC3HDC8
UniProt ID: (Mouse) Q9JJ48
Entrez Gene ID: (Mouse) 57432
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
RNA binding
sequence-specific DNA binding
poly(A) RNA binding
metal ion binding
zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
apoptotic process
negative regulation of T cell differentiation in thymus
snRNA transcription from RNA polymerase II promoter
snRNA transcription from RNA polymerase III promoter
T cell homeostasis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase III promoter
response to antibiotic
positive regulation of thymocyte apoptotic process
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