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Abnova
ZCCHC3 Polyclonal Antibody, MaxPab™
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产品信息
H00085364-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ZCCHC3 (NP_149080, 1 a.a. approximately 403 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MATGGGAEEE RKRGRPQLLP PARPAARGEE ADGGREKMGW AQVVKNLAEK KGEFREPRPP RREEESGGGG GSAGLGGPAG LAAPDLGDFP PAGRGDPKGR RRDPAGEAVD PRKKKGAAEA GRRKKAEAAA AAMATPARPG EAEDAAERPL QDEPAAAAGP GKGRFLVRIC FQGDEGACPT RDFVVGALIL RSIGMDPSDI YAVIQIPGSR EFDVSFRSAE KLALFLRVYE EKREQEDCWE NFVVLGRSKS SLKTLFILFR NETVDVEDIV TWLKRHCDVL AVPVKVTDRF GIWTGEYKCE IELRQGEGGV RHLPGAFFLG AERGYSWYKG QPKTCFKCGS RTHMSGSCTQ DRCFRCGEEG HLSPYCRKGI VCNLCGKRGH AFAQCPKAVH NSVAAQLTGV AGH
靶标信息
Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30193849, PubMed:30135424). Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as DDX58/RIG-I, IFIH1/MDA5 and CGAS (PubMed:30193849, PubMed:30135424). Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (PubMed:30135424). Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (PubMed:30135424). Promotes sensing of viral RNA by RIG-I-like receptors proteins DDX58/RIG-I and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of DDX58/RIG-I and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of DDX58/RIG-I and IFIH1/MDA5 (PubMed:30193849). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Zinc finger CCHC domain-containing protein 3; zinc finger, CCHC domain containing 3
基因别名: C20orf99; ZCCHC3
UniProt ID: (Human) Q9NUD5
Entrez Gene ID: (Human) 85364
