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ZCP1/Zinc Chaperone Protein Polyclonal Antibody
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ZCP1/Zinc Chaperone Protein Antibody (AS14-2770) in WB
Chlamydomonas reinhardtii whole-cell extracts corresponding to 10 µL 1 x 10 7 cells/mL per well (except dilutions as indicated) were separated on a 12% SDS-PAGE gel and blotted to nitrocellulose for 90 min. at 1.5 m A cm-2. The membrane was blocked with 1% bovine calf serum in PBS-T overnight at 4 deg C. Blot was incubated in the primary antibody at a dilution of 1:1,000 for 2 hr at RT with agitation. The a... View More
产品信息
AS14-2770
产品规格
种属反应
Algae
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
Recombinant, full length ZCP1 protein of Chlamydomonas reinhardtii.
偶联物
形式
Lyophilized
保存液
whole serum
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Chlamydomonas reinhardtii
靶标信息
ZCP1 (zona pellucida glycoprotein 1; ZP1) encodes a secreted, extracellular matrix glycoprotein that is synthesized by growing oocytes and incorporated into the zona pellucida surrounding the oocyte and early embryo. The gene produces multiple transcripts and a protein characterized by an N-terminal signal peptide for secretion and a conserved zona pellucida (ZP) domain (approximately 270 amino acids with conserved cysteines forming intramolecular disulfide bonds) that supports polymerization/assembly with other ZP proteins; in the assembled matrix, ZP1 functions primarily as a structural cross-linker that stabilizes and reinforces the fibrillar scaffold built largely from ZP2-ZP3, thereby maintaining zona pellucida integrity required for normal fertilization and preimplantation development. Experimental and clinical genetics evidence links loss-of-function or damaging variants in ZP1 to defective or absent zona pellucida, oocyte maturation defects, and female infertility, consistent with its essential role in constructing a functional oocyte coat.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: COG0523; ZNG1
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