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Bethyl Laboratories
ZEB2/SIP Polyclonal Antibody
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Product Details
A302-474A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1164 and 1214 of Human Smad interacting-protein 1.
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HRIHFB2411; SMAD interacting protein 1; Smad-interacting protein 1; SMADIP1; unnamed protein product; Zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; Zinc finger homeobox protein 1b
Gene Aliases: HRIHFB2411; HSPC082; KIAA0569; SIP-1; SIP1; SMADIP1; ZEB2; ZFHX1B; ZFX1B
UniProt ID: (Human) O60315
Entrez Gene ID: (Human) 9839
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
protein binding
zinc ion binding
phosphatase regulator activity
metal ion binding
R-SMAD binding
negative regulation of transcription from RNA polymerase II promoter
neural crest cell migration
somitogenesis
neural tube closure
endothelial cell proliferation
regulation of transcription from RNA polymerase II promoter
nervous system development
central nervous system development
negative regulation of fibroblast migration
corpus callosum morphogenesis
hippocampus development
cell proliferation in forebrain
corticospinal tract morphogenesis
positive regulation of Wnt signaling pathway
positive regulation of transforming growth factor beta receptor signaling pathway
myofibroblast differentiation
stress fiber assembly
endothelial cell migration
positive regulation of melanocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of melanin biosynthetic process
developmental pigmentation
astrocyte activation
embryonic morphogenesis
collateral sprouting
positive regulation of axonogenesis
mammillary axonal complex development
pyroptosis
fibroblast activation
positive regulation of canonical Wnt signaling pathway
response to oxygen-glucose deprivation
melanocyte migration
positive regulation of lens fiber cell differentiation
regulation of melanosome organization
positive regulation of myofibroblast contraction
regulation of myofibroblast cell apoptotic process
regulation of blood-brain barrier permeability
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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