Invitrogen

ZFPM1 Polyclonal Antibody

查看其他9个ZFPM1抗体

问题与答案

问题与答案

Immunogen image

ZFPM1 Polyclonal Antibody

Immunogen Image ZFPM1 Polyclonal Antibody

产品信息

PA5-68795

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.2-1.0 µg/mL

-

产品规格

种属反应

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

synthetic peptide directed towards the N terminal region of mouse ZFPM1

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

This target displays homology in the following species: Mouse: 100%; Rat: 85%

靶标信息

ZFPM1 is a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM1 is an essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. ZFPM1 may be involved in regulation of some genes in gonads. ZFPM1 may also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: FOG-1; Friend of GATA 1; Friend of GATA protein 1; Friend of GATA-1; Zinc finger protein multitype 1; Zinc finger protein ZFPM1

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基因别名: FOG; Fog1; Zfpm1

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UniProt ID: (Mouse) O35615

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Entrez Gene ID: (Mouse) 22761

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transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding nucleic acid binding DNA binding transcription corepressor activity protein binding transcription factor binding metal ion binding transcription cofactor

negative regulation of transcription from RNA polymerase II promoter outflow tract morphogenesis atrioventricular valve morphogenesis mitral valve formation tricuspid valve formation transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter heart development regulation of definitive erythrocyte differentiation erythrocyte differentiation megakaryocyte differentiation platelet formation granulocyte differentiation negative regulation of protein binding regulation of chemokine production embryonic hemopoiesis megakaryocyte development positive regulation of interferon-gamma biosynthetic process negative regulation of interleukin-4 biosynthetic process negative regulation of fat cell differentiation positive regulation of transcription from RNA polymerase II promoter homeostasis of number of cells cardiac muscle tissue morphogenesis definitive erythrocyte differentiation primitive erythrocyte differentiation negative regulation of mast cell differentiation ventricular septum morphogenesis atrial septum morphogenesis transcriptional activation by promoter-enhancer looping