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Positive test controls include: U-251MG, 293T, Raji, LO2, Mouse brain.
Immunogen sequence: SDHRYRCQRG IVHITSESLA KDQLAIAASR HGRTYHAYPD FAPQKFKEKT QGQVKILEDS FLKSSFPTQA ELDRLRVETK LSRREIDSWF SERRKLRDSM EQAVLDSMGS GKKGQDVGAP NGALSRLDQL SGAQLTSSLP SPSPAIAKSQ EQVHLLRSTF ARTQWPTPQE YDQLAAKTGL VRTEIVRWFK ENRCLLKTGT VKWMEQYQHQ PMADDHGYDA VARKATKPMA ESPKNGGDVV PQYYKDPKKL CEEDLEKLVT RVKVGSEPAK DCLPAKPSEA TSDRSEGSSR DGQGSDENEE SSVVDYVEVT VGEEDAISDR SDSWSQAAAE GVSELAESDS DCVPAEAGQA
Zinc-fingers and homeobox (ZHX) proteins are transcription factors that interact with the activation domain of the A subunit of nuclear factor-Y (NF-YA). ZHX1-3 are ubiquitously expressed proteins expressed in various tissues. They act as transcriptional repressors and localize to the nucleus. The ZHX proteins contain two Cys(2)-His(2)-type zinc-finger motifs and five homeodomains (HDs). These domains allow the ZHX proteins to form homodimers, but they can also form heterodimers with each other. However, this dimerization is not required for repressor activity. Hypermethylation-mediated silencing of ZHX2 is an epigenetic event involved in hepatocellular carcinoma (HCC).
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: AFP regulator 1; alpha fetoprotein regulation 1, adult; Alpha-fetoprotein regulator 1; Regulator of AFP; transcription factor ZHX2; Zinc finger and homeodomain protein 2; Zinc fingers and homeoboxes protein 2; zinc-fingers and homeoboxes 2
基因别名: Afr-1; AFR1; KIAA0854; mKIAA0854; RAF; ZHX2
UniProt ID: (Human) Q9Y6X8, (Rat) Q80VX4, (Mouse) Q8C0C0
Entrez Gene ID: (Human) 22882, (Rat) 314988, (Mouse) 387609
分子生物学功能: homeodomain transcription factor