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Invitrogen
ZMYND10 Polyclonal Antibody
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产品信息
PA5-21864
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human BLU. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: 293T, A431, H1299, Raji.
Predicted reactivity: Mouse (100%), Rat (100%), Chimpanzee (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The ZMYND10 gene encodes a protein that contains a MYND-type zinc finger domain, playing a crucial role in the assembly and function of cilia. Specifically, ZMYND10 is essential for the proper axonemal assembly of both inner and outer dynein arms, which are critical components of motile cilia. Mutations in ZMYND10 are associated with primary ciliary dyskinesia (PCD), a genetic disorder characterized by defective ciliary motility leading to recurrent respiratory infections and male infertility. In model organisms like mice and Drosophila, ZMYND10 expression is restricted to tissues and cells with motile cilia, such as chordotonal sensory neurons and sperm cells. Additionally, ZMYND10 has been identified as an epigenetically regulated tumor suppressor in various cancers, with its downregulation affecting processes like cell proliferation and tumor progression. The gene's dual role in ciliary function and tumorigenesis underlines its importance in both normal cellular physiology and disease pathology.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Protein BLu; Zinc finger MYND domain-containing protein 10; zinc finger, MYND-type containing 10
基因别名: BLU; CILD22; FLU; LUCA12.4; ZMYND10
UniProt ID: (Human) O75800
Entrez Gene ID: (Human) 51364
