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Abnova
ZMYND10 Monoclonal Antibody (3A6)
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产品信息
H00051364-M05
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
3A6
抗原
ZMYND10 (AAH33732, 1 a.a. approximately 440 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: MGDLELLLPG EAEVLVRGLR SFPLREMGSE GWNQQHENLE KLNMQAILDA TVSQGEPIQE LLVTHGKVPT LVEELIAVEM WKQKVFPVFC RVEDFKPQNT FPIYMVVHHE ASIINLLETV FFHKEVCESA EDTVLDLVDY CHRKLTLLVA QSGCGGPPEG EGSQDSNPMQ ELQKQAELME FEIALKALSV LRYITDCVDS LSLSTLSRML STHNLPCLLV ELLEHSPWSR REGGKLQQFE GSRWHTVAPS EQQKLSKLDG QVWIALYNLL LSPEAQARYC LTSFAKGRLL KLRAFLTDTL LDQLPNLAHL QSFLAHLTLT ETQPPKKDLV LEQIPEIWER LERENRGKWQ AIAKHQLQHV FSPSEQDLRL QARRWAETYR LDVLEAVAPE RPRCAYCSAE ASKRCSRCQN EWYCCRECQV KHWEKHGKTC VLAAQGDRAK
靶标信息
The ZMYND10 gene encodes a protein that contains a MYND-type zinc finger domain, playing a crucial role in the assembly and function of cilia. Specifically, ZMYND10 is essential for the proper axonemal assembly of both inner and outer dynein arms, which are critical components of motile cilia. Mutations in ZMYND10 are associated with primary ciliary dyskinesia (PCD), a genetic disorder characterized by defective ciliary motility leading to recurrent respiratory infections and male infertility. In model organisms like mice and Drosophila, ZMYND10 expression is restricted to tissues and cells with motile cilia, such as chordotonal sensory neurons and sperm cells. Additionally, ZMYND10 has been identified as an epigenetically regulated tumor suppressor in various cancers, with its downregulation affecting processes like cell proliferation and tumor progression. The gene's dual role in ciliary function and tumorigenesis underlines its importance in both normal cellular physiology and disease pathology.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Protein BLu; Zinc finger MYND domain-containing protein 10; zinc finger, MYND-type containing 10
基因别名: BLU; CILD22; FLU; LUCA12.4; ZMYND10
UniProt ID: (Human) O75800
Entrez Gene ID: (Human) 51364
