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Invitrogen
ZNF304 Polyclonal Antibody
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产品信息
PA5-107319
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the N terminal region of human ZNF304 (aa 1-51).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.4, with 2% sucrose
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Sequence homology: Cow: 77%; Dog: 100%; Horse: 92%; Human: 100%; Mouse: 77%; Pig: 77%; Rat: 93%
靶标信息
ZNF304 acts as transcriptional regulator and plays a role in gene silencing. It probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. ZNF304 is also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of Lysine-27 of histone H3 (H3K27me3) in a Polycomb group (PcG) complexes-dependent manner. The protein associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites. It acts as a transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways. It associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression. It promotes angiogenesis and tumor growth.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: KRAB-containing zinc finger protein; Zinc finger protein 304
基因别名: ZNF304
UniProt ID: (Human) Q9HCX3
Entrez Gene ID: (Human) 57343
angiogenesis
transcription, DNA-templated
integrin-mediated signaling pathway
Ras protein signal transduction
covalent chromatin modification
positive regulation of cell migration
negative regulation of chromatin binding
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
positive regulation of epithelial cell proliferation
positive regulation of methylation-dependent chromatin silencing
positive regulation of histone H3-K9 trimethylation
positive regulation of histone H3-K27 trimethylation
negative regulation of anoikis
