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Peptide sequence: YTVCDKSFHQ SSALLQHQTV HIGEKPFVCN VSEKGLELSP PHASEASQMS
Sequence homology: Cow: 85%; Dog: 100%; Goat: 92%; Horse: 100%; Human: 100%; Mouse: 79%; Pig: 92%; Rabbit: 92%; Rat: 79%
ZNF322 contains four exons and spans 23.2kb in chromosome 6p22.1 region, and transcribes a 2.7kb mRNA that encodes a protein with 402 amino acid residues.Through northern blot analysis, ZNF322 was shown to be expressed in every human tissue examined at adult stage and during embryonic developmental stages from 80 days to 24 weeks. When ZNF322 was overexpressed in COS-7 cells, ZNF322-EGFP fusion protein is detected in the nucleus and cytoplasm. Reporter gene assays show that ZNF322 is a transcriptional activator. Furthermore, overexpression of ZNF322 in COS-7 cells activates the transcriptional activity of SRE and AP-1. Together, these results suggest that ZNF322 is a member of the zinc-finger transcription factor family and may act as a positive regulator in gene transcription mediated by the MAPK signaling pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: HLA complex group 12; Zinc finger protein 322; Zinc finger protein 322A; Zinc finger protein 388; Zinc finger protein 489
基因别名: HCG12; ZNF322; ZNF322A; ZNF388; ZNF489
UniProt ID: (Human) Q6U7Q0
Entrez Gene ID: (Human) 79692
分子生物学功能: DNA-binding transcription factor C2H2 zinc finger transcription factor