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Invitrogen
ZNF354C Biosimilar Recombinant Human Monoclonal Antibody
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产品信息
MA5-59477
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term Macrogenics patent anti-KID3.
靶标信息
ZNF354C (Zinc Finger Protein 354C) is located on chromosome 5 and functions primarily as a transcriptional repressor. It is characterized by the presence of a KRAB (Kruppel-associated box) domain, which is essential for its repressive activity. The KRAB domain interacts with various co-repressors to inhibit the transcription of specific genes. ZNF354C is involved in several biological processes, including suppressing endothelial angiogenic sprouting by inhibiting gene expression via its KRAB domain. Additionally, ZNF354C is implicated in the regulation of the tissue factor pathway inhibitor (TFPI) by influencing promoter methylation patterns, which can affect cellular processes such as proliferation, migration, and the response to ischemia/reperfusion injury. Genome-Wide Association Studies (GWAS) have identified variants in ZNF354C that are associated with certain immune responses, highlighting its potential role in mediating disease pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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