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This gene contains long CAG trinucleotide repeats coding consecutive glutamine residues. The gene product may functions as a transcription factor, with a potential role in the regulation of neurodevelopment or neuroplasticity. The protein appears to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Multiple transcript variants encoding several isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CAG repeat protein 1; CAS-interacting zinc finger protein; expanded repeat domain, CAG/CTG 2; Nuclear matrix protein 4; Nuclear matrix transcription factor 4; Trinucleotide repeat-containing gene 1 protein; Zinc finger protein 384
基因别名: CAGH1; CAGH1A; CIZ; ERDA2; NMP4; NP; TNRC1; ZNF384
UniProt ID: (Human) O15407
Entrez Gene ID: (Human) 171017, (Pig) 100516975