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Invitrogen
ZNF496 Polyclonal Antibody
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产品信息
PA5151173
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
The immunogen is a synthetic peptide corresponding to a region of mouse ZNF496.
偶联物
形式
Liquid
浓度
0.5 mg/mL
规格
50 µg
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
ZNF496 contains a SCAN box, a KRAB-A domain, and four consensus C2H2-type zinc fingers preceded by a unique finger derivative, referred to herein as the C2HR motif. The C2HR motif functions to mediate protein-protein interaction with the cysteine-rich (C5HCH) domain of NSD1 in a Zn(II)-dependent fashion, and when tethered to RNA polymerase II promoters, represses transcription in an NSD1-dependent manner. ZNF496 contains a novel type of zinc finger motif that functions as a docking site for NSD1 and is more than just a degenerate evolutionary remnant of a C2H2 motif.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC15548; NSD1-interacting zinc finger protein 1; Zinc finger protein 496; Zinc finger protein with KRAB and SCAN domains 17
基因别名: Nizp1; Nizp11; Zfp496; Zkscan17; Znf496
UniProt ID: (Mouse) Q5SXI5
Entrez Gene ID: (Mouse) 268417
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