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Abnova
ZNF496 Monoclonal Antibody (4B1)
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产品信息
H00084838-M02
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
4B1
抗原
ZNF496 (NP_116141, 485 a.a. approximately 585 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: HLQPDRLQPV EKREQAASED ADKGPKEPLE NGKAKLSFQC CECGKAFQRH DHLARHRSHF HLKDKARPFQ CRYCVKSFTQ NYDLLRHERL HMKRRSKQAL N
靶标信息
ZNF496 contains a SCAN box, a KRAB-A domain, and four consensus C2H2-type zinc fingers preceded by a unique finger derivative, referred to herein as the C2HR motif. The C2HR motif functions to mediate protein-protein interaction with the cysteine-rich (C5HCH) domain of NSD1 in a Zn(II)-dependent fashion, and when tethered to RNA polymerase II promoters, represses transcription in an NSD1-dependent manner. ZNF496 contains a novel type of zinc finger motif that functions as a docking site for NSD1 and is more than just a degenerate evolutionary remnant of a C2H2 motif.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC15548; NSD1 (nuclear receptor binding SET-domain containing 1)-interacting zinc finger protein 1; Zinc finger protein 496; Zinc finger protein with KRAB and SCAN domains 17
基因别名: NIZP1; ZFP496; ZKSCAN17; ZNF496; ZSCAN49
UniProt ID: (Human) Q96IT1
Entrez Gene ID: (Human) 84838
