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Abnova
ZNF83 Polyclonal Antibody, MaxPab™
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产品信息
H00055769-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ZNF83 (AAH50407.1, 1 a.a. approximately 516 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MHGRKDDAQK QPVKNQLGLN PQSHLPELQL FQAEGKIYKY DHMEKSVNSS SLVSPPQRIS STVKTHISHT YECNFVDSLF TQKEKANIGT EHYKCNERGK AFHQGLHFTI HQIIHTKETQ FKCDICGKIF NKKSNLASHQ RIHTGEKPYK CNECGKVFHN MSHLAQHRRI HTGEKPYKCN ECGKVFNQIS HLAQHQRIHT GEKPYKCNEC GKVFHQISHL AQHRTIHTGE KPYECNKCGK VFSRNSYLVQ HLIIHTGEKP YRCNVCGKVF HHISHLAQHQ RIHTGEKPYK CNECGKVFSH KSSLVNHWRI HTGEKPYKCN ECGKVFSHKS SLVNHWRIHT GEKPYKCNEC GKVFSRNSYL AQHLIIHAGE KPYKCDECDK AFSQNSHLVQ HRRIHTGEKP YKCDECGKVF SQNSYLAYHW RIHTGEKAYK CNECGKVFGL NSSLAHHRKI HTGEKPFKCN ECGKAFSMRS SLTNHHAIHT GEKHFKCNEC GKLFRDNSYL VRHQRFHAGK KSNTCN
靶标信息
The ZNF83 gene encodes a zinc-finger protein belonging to a large family of transcription factors that play essential roles in regulating gene expression by interacting with DNA. Located on chromosome 3, ZNF83 is particularly notable for its recurrent mutations in cancer. For instance, the p.E293V missense mutation in ZNF83 has been frequently observed in bladder cancer patients, accounting for 18% of cases, and is associated with poor prognosis. This mutation disrupts the gene's tumor suppressor function, promoting increased tumor growth. Due to its significant role in tumorigenesis, ZNF83 is actively studied in cancer research as a potential biomarker and therapeutic target.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Zinc finger protein 816B; Zinc finger protein 83; Zinc finger protein HPF1
基因别名: HPF1; ZNF816B; ZNF83
UniProt ID: (Human) P51522
Entrez Gene ID: (Human) 55769
