Invitrogen

alpha-1a Adrenergic Receptor Recombinant Rabbit Monoclonal Antibody (JE62-50)

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说明书
实验方案
问题与答案
技术支持
alpha-1a Adrenergic Receptor Recombinant Rabbit Monoclonal Antibody (JE62-50)

产品信息

MA5-44824

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-

免疫细胞化学 (ICC/IF)

1:50-1:100
-

流式细胞分析 (Flow)

1:500-1:1,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

JE62-50

抗原

Synthetic peptide within human alpha 1a Adrenergic Receptor aa 200-250/466.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 40% glycerol, 0.05% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2931281

靶标信息

Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence. A1AR subtypes are found in numerous tissues and have been shown to be involved in the regulation of blood pressure due to changes in vascular tone and cardiac output. Effects on uterine contraction, hepatic glucose metabolism, heat shock protein 70 (HSP70), proto-oncogene expression, and mitogenesis have been linked to A1AR activation. Norepinephrine can increase nitric oxide synthase (NOS) levels in the hypothalamus by activating alpha-1 AR which may indirectly suppress the release of luteinizing hormone (LH), the androgens, estrogen, and progesterone.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: ADA1; adrenergic alpha 1c receptor; adrenergic receptor alpha 1c subtype; adrenergic receptor, alpha 1a; adrenergic receptor, alpha 1c; adrenergic, alpha-1A-, receptor; alpha 1A-adrenoceptor; alpha 1A-adrenoreceptor; alpha 1C-adrenergic receptor; Alpha-1A adrenergic receptor; Alpha-1A adrenoceptor; Alpha-1A adrenoreceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c; Alpha1C-AR; G protein coupled receptor

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基因别名: ADRA1A; ADRA1C; ADRA1L1; ALPHA1AAR

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UniProt ID: (Human) P35348, (Mouse) P97718, (Rat) P43140

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Entrez Gene ID: (Human) 148, (Mouse) 11549, (Rat) 29412

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功能
alpha1-adrenergic receptor activity protein heterodimerization activity signal transducer activity G-protein coupled receptor activity adrenergic receptor activity G-protein coupled receptor
参与通路
negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure positive regulation of heart rate by epinephrine-norepinephrine positive regulation of the force of heart contraction by epinephrine-norepinephrine positive regulation of systemic arterial blood pressure apoptotic process smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway activation of phospholipase C activity positive regulation of cytosolic calcium ion concentration cell-cell signaling adult heart development aging negative regulation of cell proliferation response to hormone cell growth positive regulation of synaptic transmission, GABAergic negative regulation of Rho protein signal transduction organ growth intracellular signal transduction response to drug positive regulation of MAPK cascade positive regulation of action potential positive regulation of vasoconstriction positive regulation of smooth muscle contraction micturition calcium ion transport into cytosol positive regulation of cardiac muscle contraction positive regulation of ERK1 and ERK2 cascade adenylate cyclase-activating adrenergic receptor signaling pathway positive regulation of protein kinase C signaling pilomotor reflex regulation of muscle contraction positive regulation of heart rate regulation of vasoconstriction regulation of cardiac muscle contraction adrenergic receptor signaling pathway
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