Alomone Labs, LTD

alpha 2A-Adrenergic Receptor (extracellular) Polyclonal Antibody

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说明书
实验方案
问题与答案
技术支持
alpha 2A-Adrenergic Receptor (extracellular) Polyclonal Antibody

产品信息

AAR-020-200UL

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:200
-

免疫组化（冰冻） (IHC (F))

1:250
-

流式细胞分析 (Flow)

5 µg
-
产品规格

种属反应

Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

(C)DAGNSSWNGTEAPG, corresponding to amino acid residues 7-20 of rat alpha 2A-adrenoceptor, Extracellular, N-terminus
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.85 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

Alpha-2-adrenergic receptors (ADRA2A) are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. ADRA2A mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G protein. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: adrenergic receptor, alpha 2a; adrenergic, alpha-2A-, receptor; Alpha-2A adrenergic receptor; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; alpha-2AAR; Alpha-2D adrenergic receptor; alpha2A-adrenergic receptor; CA2-47; OTTHUMP00000058849; subtype alpha2-C10

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基因别名: Adra-2; Adra-2a; Adra2a; alpha(2A)AR; alpha2-C10; alpha2A; alpha2A-AR; AW122659; CA2-47; RATRG20; RG20

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UniProt ID: (Mouse) Q01338, (Rat) P22909

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Entrez Gene ID: (Mouse) 11551, (Rat) 25083

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功能
adrenergic receptor activity alpha2-adrenergic receptor activity protein kinase binding alpha-2C adrenergic receptor binding thioesterase binding heterotrimeric G-protein binding protein homodimerization activity protein heterodimerization activity epinephrine binding norepinephrine binding G-protein coupled receptor
参与通路
positive regulation of cytokine production acute inflammatory response DNA replication G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity cell-cell signaling female pregnancy negative regulation of norepinephrine secretion positive regulation of cell migration negative regulation of cAMP biosynthetic process activation of protein kinase activity activation of protein kinase B activity cellular response to hormone stimulus epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway glucose homeostasis fear response positive regulation of MAP kinase activity positive regulation of epidermal growth factor-activated receptor activity positive regulation of vasodilation negative regulation of calcium ion-dependent exocytosis negative regulation of insulin secretion thermoception negative regulation of lipid catabolic process positive regulation of membrane protein ectodomain proteolysis negative regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of uterine smooth muscle contraction adrenergic receptor signaling pathway adenylate cyclase-inhibiting adrenergic receptor signaling pathway phospholipase C-activating adrenergic receptor signaling pathway activation of MAPK activity by adrenergic receptor signaling pathway positive regulation of wound healing regulation of smooth muscle contraction signal transduction regulation of vasoconstriction platelet activation
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