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Invitrogen
alpha-2a Adrenergic Receptor Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA1-30159
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)KASRWRGRQNREKR
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
50 µg
纯化类型
Affinity chromatography
保存液
PBS
内含物
0.05% Sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Alpha-2-adrenergic receptors (ADRA2A) are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. ADRA2A mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G protein. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: adrenergic receptor, alpha 2a; adrenergic, alpha-2A-, receptor; alpha-2 adrenergic receptor subtype C10; alpha-2-adrenergic receptor, platelet type; alpha-2A adrenoceptor; alpha-2A adrenoreceptor; alpha-2AAR; alpha-2AAR subtype C10; alpha-2D adrenergic receptor; alpha2A-adrenergic receptor; OTTHUMP00000058849; subtype alpha2-C10; unnamed protein product
基因别名: Adra-2; Adra-2a; ADRA2; ADRA2R; ADRAR; alpha(2A)AR; alpha2-C10; alpha2A; alpha2A-AR; ALPHA2AAR; CA2-47; FPLD8; RATRG20; RG20
UniProt ID: (Human) P08913, (Mouse) Q01338, (Rat) P22909
Entrez Gene ID: (Human) 150, (Mouse) 11551, (Rat) 25083
G-protein coupled receptor activity
adrenergic receptor activity
alpha2-adrenergic receptor activity
protein binding
protein kinase binding
alpha-1B adrenergic receptor binding
alpha-2C adrenergic receptor binding
thioesterase binding
heterotrimeric G-protein binding
protein homodimerization activity
epinephrine binding
norepinephrine binding
protein heterodimerization activity
positive regulation of cytokine production
DNA replication
regulation of smooth muscle contraction
epidermal growth factor receptor signaling pathway
G-protein coupled receptor signaling pathway
female pregnancy
negative regulation of norepinephrine secretion
regulation of vasoconstriction
platelet activation
positive regulation of cell migration
cellular response to hormone stimulus
vasodilation
glucose homeostasis
fear response
response to morphine
positive regulation of MAPK cascade
positive regulation of epidermal growth factor receptor signaling pathway
negative regulation of calcium ion-dependent exocytosis
negative regulation of insulin secretion
thermoception
negative regulation of lipid catabolic process
positive regulation of membrane protein ectodomain proteolysis
positive regulation of protein kinase B signaling
negative regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of uterine smooth muscle contraction
adrenergic receptor signaling pathway
adenylate cyclase-activating adrenergic receptor signaling pathway
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
phospholipase C-activating adrenergic receptor signaling pathway
positive regulation of wound healing
response to alcohol
presynaptic modulation of chemical synaptic transmission
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
Ras protein signal transduction
Rho protein signal transduction
positive regulation of cell proliferation
actin cytoskeleton organization
negative regulation of epinephrine secretion
positive regulation of potassium ion transport
intestinal absorption
negative regulation of calcium ion transport
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