Invitrogen

alpha-2c Adrenergic Receptor Monoclonal Antibody (N330A/80), PerCP

Name: alpha-2c Adrenergic Receptor Monoclonal Antibody (N330A\/80), PerCP
Brand: Invitrogen
SKU: MA5-45617

查看其他21个alpha-2c Adrenergic Receptor抗体

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实验方案

问题与答案

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说明书

实验方案

问题与答案

技术支持

抗体检测数据 (3)

alpha-2c Adrenergic Receptor Antibody in Immunocytochemistry (ICC/IF)

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alpha-2c Adrenergic Receptor Antibody (MA5-45617) in ICC/IF

Immunocytochemistry/Immunofluorescence analysis using human neuroblastoma cells. Fixation involved 4% Formaldehyde for 15 min at RT. Samples were incubated with Alpha-2C Adrenergic Receptor monoclonal antibody (Product # MA5-45617) at 1:100 for 60 min at RT, followed by Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain used was Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at ... View More

alpha-2c Adrenergic Receptor Antibody in Western Blot (WB)

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Immunogen Image alpha-2c Adrenergic Receptor Monoclonal Antibody (N330A/80), PerCP

产品信息

MA5-45617

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

免疫细胞化学 (ICC/IF)

Assay-dependent

产品规格

种属反应

Human, Mouse

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

N330A/80

抗原

Synthetic peptide amino acids 442- 462 (QDFRRSFKHILFRRRRRGFRQ, cytoplasmic C-terminus) of human Alpha-2C adrenergic receptor

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偶联物

PerCP PerCP PerCP

激发/发射光谱

482/675 nm 查看光谱

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA

内含物

no preservative

保存条件

4°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2932071

产品详细信息

1 µg/mL of MA5-45617 was sufficient for detection of Alpha2C Adrenergic Receptor in 20 µg of COS cells transiently transfected with HA-tagged Alpha- lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. |Detects 50kDa or larger (possibly due to dimerization). Does not cross-react with other adrenergic receptors.

This antibody was formerly sold as clone S330A-80.

靶标信息

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Adra 2c; adrenergic, alpha-2C-, receptor; Alpha 2CAR; Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenergic receptor; Alpha-2C adrenoceptor; Alpha-2C adrenoreceptor; alpha-2C-adrenergic receptor; Alpha-2C-AR; alpha-2CAR; alpha2 AR C4; alpha2 C4; alpha2-AR-C4; subtype alpha2-C4

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基因别名: [a]2C; Adra-2c; ADRA2C; ADRA2L2; ADRA2RL2; ADRARL2; alpha2-C4; alpha2C; ALPHA2CAR

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UniProt ID: (Human) P18825, (Mouse) Q01337

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Entrez Gene ID: (Human) 152, (Mouse) 11553

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