Invitrogen

alpha Actinin 2 Recombinant Rabbit Monoclonal Antibody (7H1L69)

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alpha Actinin 2 Recombinant Rabbit Monoclonal Antibody (7H1L69)

产品信息

701914

应用
建议稀释比
已发表文章

免疫印迹 (WB)

0.5 µg/mL
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免疫组化 (IHC)

-
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免疫组化（石蜡） (IHC (P))

-
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免疫组化（冰冻） (IHC (F))

2 µg/mL
-

免疫细胞化学 (ICC/IF)

1:100
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免疫沉淀 (IP)

-
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产品规格

种属反应

Human, Mouse, Rat

已发表种属

C. elegans, Human, Mouse

宿主/亚型

Rabbit / IgG

Expression System

Expi293

分类

Recombinant Monoclonal

类型

Antibody

克隆号

7H1L69

抗原

Peptides corresponding to human Sarcomeric alpha actinin/alpha actinin 2 [1) aa834-aa852, 2) aa5-aa24]
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2688290

产品详细信息

This antibody is predicted to react with Monkey, Pig, Rat, Mouse

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

靶标信息

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it i involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: actinin, alpha 2; alpha-actinin skeletal muscle; Alpha-actinin skeletal muscle isoform 2; Alpha-actinin-2; F-actin cross-linking protein

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基因别名: 1110008F24Rik; ACTN2; CMD1AA; CMH23

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UniProt ID: (Human) P35609, (Mouse) Q9JI91

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Entrez Gene ID: (Human) 88, (Mouse) 11472, (Rat) 291245

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功能
Ras guanyl-nucleotide exchange factor activity integrin binding calcium ion binding protein binding phosphatidylinositol-4,5-bisphosphate binding cytoskeletal protein binding structural constituent of muscle protein domain specific binding LIM domain binding thyroid hormone receptor coactivator activity titin binding identical protein binding protein homodimerization activity ion channel binding protein dimerization activity actin filament binding FATZ binding titin Z domain binding actin binding ligand-dependent nuclear receptor transcription coactivator activity protein binding, bridging metal ion binding
参与通路
MAPK cascade platelet degranulation cell adhesion microspike assembly muscle filament sliding regulation of membrane potential regulation of apoptotic process negative regulation of potassium ion transport positive regulation of potassium ion transport positive regulation of GTPase activity sarcomere organization focal adhesion assembly protein homotetramerization actin filament uncapping cardiac muscle cell development phospholipase C-activating angiotensin-activated signaling pathway establishment of protein localization to plasma membrane negative regulation of potassium ion transmembrane transporter activity positive regulation of potassium ion transmembrane transporter activity regulation of nucleic acid-templated transcription negative regulation of protein localization to cell surface positive regulation of receptor activity positive regulation of endocytic recycling positive regulation of cation channel activity muscle contraction
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