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Invitrogen
alpha Actinin 3 Polyclonal Antibody
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alpha Actinin 3 Antibody (PA5-36233) in IHC (P)
Immunohistochemistry analysis of alpha Actinin 3 in paraffin-embedded human kidney carcinoma tissue (cytoplasmic and nucleus staining) and negative control (right, with PBS only). Samples were incubated with alpha Actinin 3 polyclonal antibody (Product # PA5-36233) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
产品信息
PA5-36233
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the N-terminus of human Actinin-alpha3
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody detects endogenous protein at a molecular weight of 103 kDa. It does not cross-react with other alpha-actinin isoforms.
Purity is >95% by SDS-PAGE.
靶标信息
Alpha-actinin-3, also known as alpha-actinin skeletal muscle isoform 3 or F-actin cross-linking protein, is a protein that in humans is encoded by the ACTN3 gene. This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the coding allele.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Actinin alpha3; actinin, alpha 3; Actinin-alpha3; alpha-actinin skeletal muscle; Alpha-actinin skeletal muscle isoform 3; Alpha-actinin-3; alpha-Actinin3; alphaActinin-3; F-actin cross-linking protein
基因别名: ACTN3
UniProt ID: (Human) Q08043, (Mouse) O88990
Entrez Gene ID: (Human) 89, (Mouse) 11474, (Rat) 171009
regulation of the force of skeletal muscle contraction
skeletal muscle atrophy
transition between fast and slow fiber
response to denervation involved in regulation of muscle adaptation
muscle filament sliding
regulation of apoptotic process
negative regulation of glycolytic process
focal adhesion assembly
positive regulation of skeletal muscle tissue growth
negative regulation of calcineurin-NFAT signaling cascade
negative regulation of oxidative phosphorylation
regulation of aerobic respiration
positive regulation of glucose catabolic process to lactate via pyruvate
muscle contraction
