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Invitrogen
alpha Adducin Polyclonal Antibody
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alpha Adducin Antibody (PA5-117767) in ICC/IF
Immunofluorescence staining of alpha Adducin in HeLa cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with alpha Adducin Polyclonal Antibody (Product # PA5-117767, 1:200) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cytoplasm and c... View More
产品信息
PA5-117767
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived Human ADD1/adducin 1 fragment
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography, Protein A
保存液
PBS, pH 7
内含物
0.03% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ADD2; ADDB; adducin 1 (alpha); Adducin beta; Adducin-1; Adducin-alpha; Adducin-beta; Adducin1; Alpha adducin; Alpha-adducin; beta Adducin; Beta-adducin; erythrocyte adducin alpha subunit; Erythrocyte adducin subunit alpha
基因别名: ADD1; ADDA
UniProt ID: (Human) P35611
Entrez Gene ID: (Human) 118
actin binding
structural molecule activity
calmodulin binding
transcription factor binding
spectrin binding
protein homodimerization activity
poly(A) RNA binding
protein heterodimerization activity
actin filament binding
cadherin binding involved in cell-cell adhesion
non-motor actin binding protein
cell morphogenesis
in utero embryonic development
cell volume homeostasis
hemoglobin metabolic process
actin cytoskeleton organization
erythrocyte differentiation
positive regulation of protein binding
multicellular organism growth
IRE1-mediated unfolded protein response
homeostasis of number of cells within a tissue
barbed-end actin filament capping
actin filament bundle assembly
transmembrane transport
cell-cell adhesion
