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Invitrogen
alpha Dystroglycan Polyclonal Antibody
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产品信息
PA5-113820
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the C-terminal region of Mouse Dag1 (aa 721-770).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: PPSPGSSAAP ATEVPDRDPE KSSEDDVYLH TVIPAVVVAA ILLIAGIIAM
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
靶标信息
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha-dystroglycan; beta-dystroglycan; Dystroglycan; Dystroglycan 1; dystrophin associated glycoprotein 1; Dystrophin-associated glycoprotein 1
基因别名: D9Wsu13e; Dag1; DG; Dp427; Dp71
UniProt ID: (Mouse) Q62165
Entrez Gene ID: (Mouse) 13138
morphogenesis of an epithelial sheet
membrane protein ectodomain proteolysis
NLS-bearing protein import into nucleus
cytoskeletal anchoring at plasma membrane
Schwann cell development
viral process
calcium-dependent cell-matrix adhesion
modulation by virus of host morphology or physiology
nerve maturation
myelination in peripheral nervous system
negative regulation of cell migration
microtubule anchoring
negative regulation of MAPK cascade
negative regulation of protein kinase B signaling
epithelial tube branching involved in lung morphogenesis
branching involved in salivary gland morphogenesis
commissural neuron axon guidance
basement membrane organization
