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Invitrogen
beta-2 Microglobulin Monoclonal Antibody (F21-21), PE
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产品信息
MA5-28738
产品规格
种属反应
Avian,
Chicken
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
F21-21
抗原
Affinity purified chicken MHC-I molecules
偶联物
激发/发射光谱
565/576 nm
查看光谱
形式
Liquid
浓度
0.1 mg/mL
纯化类型
purified
保存液
PBS, pH 7.5, with proprietary stabilizer
内含物
<0.1% sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
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生物信息学
蛋白别名: B-F; B2-microglobulin; Beta 2 microglobin; Beta 2 microglobulin; Beta-2-microglobulin; Beta2 microglobulin; MHC Class I; microglobulin beta-2; Orla-B2m
基因别名: B2M; b2m-W01; b2m-W03; b2m-Z01; b2m-Z02; b2m-Z03
UniProt ID: (Chicken) P21611
Entrez Gene ID: (Chicken) 414830
positive regulation of T cell mediated cytotoxicity
response to molecule of bacterial origin
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
positive regulation of T cell cytokine production
iron ion transport
immune response
learning or memory
negative regulation of neuron projection development
antigen processing and presentation of endogenous peptide antigen via MHC class I
T cell differentiation in thymus
regulation of iron ion transport
protein refolding
regulation of erythrocyte differentiation
positive regulation of receptor-mediated endocytosis
negative regulation of epithelial cell proliferation
protein homotetramerization
iron ion homeostasis
cellular response to iron(III) ion
cellular response to nicotine
modulation of age-related behavioral decline
negative regulation of receptor binding
positive regulation of ferrous iron binding
positive regulation of transferrin receptor binding
amyloid fibril formation
positive regulation of cellular senescence
negative regulation of forebrain neuron differentiation
