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Positive Samples: A-549, Mouse spleen; Cellular Location: Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Membrane, Nucleus, clathrin-coated pit, pseudopodium
Immunogen sequence: LASSTLLREG ANREILGIIV SYKVKVKLVV SRGGLLGDLA SSDVAVELPF TLMHPKPKEE PPHREVPENE TPVDTNLIEL DTNDDDIVFE DFARQRLKGM K
Beta Arrestin 1 is a member of a family of proteins widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of Gprotein-coupled receptors (GPCRs, e.g., beta 2-adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: arrestin; arrestin 2; Arrestin beta-1; arrestin, beta 1; beta-arrestin; Beta-arrestin-1; beta-arrestin1; Non-visual arrestin-2
基因别名: 1200006I17Rik; ARB1; ARR1; ARRB1; AW208571; BARRES; G430100A01Rik
UniProt ID: (Human) P49407, (Rat) P29066, (Mouse) Q8BWG8
Entrez Gene ID: (Human) 408, (Rat) 25387, (Mouse) 109689