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          • Primary Antibodies ›
          • beta Catenin Antibodies

          Invitrogen

          beta Catenin Monoclonal Antibody (CL3689)

          查看其他130个beta Catenin抗体

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          Cite beta Catenin Monoclonal Antibody (CL3689)

          Additional Information:
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          • 抗体检测数据 (12)
          beta Catenin Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          beta Catenin Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          图: 1 / 12

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          beta Catenin Antibody (MA573744) in ICC/IF

          Immunocytochemistry analysis of beta Catenin using A-431 cells (showing specific staining in the plasma membrane in green. Microtubule- and nuclear probes are visualized in red and blue, respectively (where available). Samples were incubated with beta Catenin monoclonal antibody (Product # MA573744). {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
          查看产品

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          beta Catenin Antibody in Immunocytochemistry (ICC/IF)
          beta Catenin Antibody in Immunocytochemistry (ICC/IF)
          beta Catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          beta Catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          beta Catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          beta Catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          beta Catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          beta Catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          beta Catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          beta Catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          beta Catenin Antibody in Western Blot (WB)
          beta Catenin Antibody in Western Blot (WB)
          beta Catenin Monoclonal Antibody (CL3689)

          产品信息

          MA573744

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1 µg/mL
          -

          免疫组化(石蜡) (IHC (P))

          1:20,000-1:50,000
          -

          免疫细胞化学 (ICC/IF)

          2-10 µg/mL
          -
          产品规格

          种属反应

          Human

          宿主/亚型

          Mouse / IgG2a

          分类

          Monoclonal

          类型

          Antibody

          克隆号

          CL3689

          抗原

          Recombinant protein fragment of Human beta Catenin (Product # RP-95297).
          3D表位/免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          1 mg/mL

          规格

          100 µg

          纯化类型

          Protein A

          保存液

          PBS, pH 7.2, with 40% glycerol

          内含物

          0.02% sodium azide

          保存条件

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          运输条件

          Ambient (domestic); Wet ice (international)

          产品详细信息

          Highest antigen sequence identity to the following orthologs: Mouse- 100%, Rat- 100%.

          靶标信息

          Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. In the nucleus, beta-catenin serves to co activate a family of Lef/Tcf transcription factors that stimulate transcription of target genes including those encoding cyclin D and c-myc that promote cell proliferation. The influence on cell proliferation is the molecular basis for the role of beta-catenin in tumorgenesis, specifically, solid tumors of the breast, colon, liver, lung, gastric, prostate, and skin.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

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          引用该产品

          生物信息学

          蛋白别名: Bcatenin; beta 1 88kDa; Beta-catenin; Betacatenin; C20orf33; Cadherin associated protein; catenin; catenin (cadherin-associated protein), beta 1, 88kDa; Catenin b 1; Catenin b1; Catenin beta-1; Catenin beta1; Catenin β 1; Catenin β1; CTNB1; dJ633O20.1; DKFZp686D02253; FLJ25606; FLJ37923; NAP; NYD-SP19; OTTHUMP00000209289; P14L; PP8304; RP5-1118M15.1; unnamed protein product; β catenin; βcatenin

          查看更多 收起

          基因别名: armadillo; CTNNB; CTNNB1; EVR7; MRD19; NEDSDV; OK/SW-cl.35; PRO2286

          查看更多 收起

          UniProt ID: (Human) P35222

          查看更多 收起

          Entrez Gene ID: (Human) 1499

          查看更多 收起

          功能
          transcription cofactor binding transcription corepressor binding chromatin binding transcription coactivator activity receptor binding protein binding ligand-dependent nuclear receptor binding enzyme binding kinase binding protein kinase binding phosphatase binding protein phosphatase binding estrogen receptor binding ubiquitin protein ligase binding ion channel binding alpha-catenin binding cadherin binding SMAD binding RNA polymerase II sequence-specific DNA binding transcription factor binding I-SMAD binding disordered domain specific binding DNA-binding transcription factor binding histone methyltransferase binding
          参与通路
          negative regulation of transcription from RNA polymerase II promoter MAPK cascade protein polyubiquitination embryonic axis specification cell morphogenesis skeletal system development patterning of blood vessels vasculogenesis osteoblast differentiation branching involved in ureteric bud morphogenesis in utero embryonic development gastrulation with mouth forming second endoderm formation cell fate specification endodermal cell fate commitment neuron migration kidney development epithelial to mesenchymal transition neural plate development tissue homeostasis vasculature development positive regulation of neuroblast proliferation positive regulation of mesenchymal cell proliferation chondrocyte differentiation lens morphogenesis in camera-type eye outflow tract morphogenesis regulation of secondary heart field cardioblast proliferation metanephros morphogenesis negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter cell adhesion cell-matrix adhesion epidermal growth factor receptor signaling pathway chemical synaptic transmission ectoderm development nervous system development glial cell fate determination neuroblast proliferation heart development protein localization cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation fibroblast growth factor receptor signaling pathway response to xenobiotic stimulus anterior/posterior axis specification dorsal/ventral axis specification dorsal/ventral pattern formation proximal/distal pattern formation mesenchymal cell proliferation gene expression regulation of gene expression positive regulation of gene expression negative regulation of gene expression regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition positive regulation of heparan sulfate proteoglycan biosynthetic process Wnt signaling pathway morphogenesis of embryonic epithelium negative regulation of angiogenesis stem cell population maintenance layer formation in cerebral cortex hypothalamus development central nervous system vasculogenesis hair cycle process hemopoiesis cell differentiation neuron differentiation T cell differentiation osteoclast differentiation lung development male genitalia development epithelial cell differentiation regulation of epithelial cell differentiation positive regulation of epithelial cell differentiation forebrain development midbrain development hindbrain development regulation of centriole-centriole cohesion pancreas development hair follicle morphogenesis regulation of protein ubiquitination regulation of myelination positive regulation of telomere maintenance via telomerase negative regulation of chondrocyte differentiation response to estradiol positive regulation of transcription elongation from RNA polymerase II promoter T cell differentiation in thymus negative regulation of protein sumoylation positive regulation of homotypic cell-cell adhesion adherens junction organization adherens junction assembly protein localization to cell surface embryonic heart tube development genitalia morphogenesis embryonic forelimb morphogenesis embryonic hindlimb morphogenesis hair cell differentiation detection of muscle stretch embryonic skeletal limb joint morphogenesis astrocyte-dopaminergic neuron signaling regulation of cell proliferation regulation of T cell proliferation odontogenesis of dentin-containing tooth embryonic digit morphogenesis regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process skin development cell-cell adhesion mediated by cadherin canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation bone resorption regulation of cell differentiation negative regulation of cell differentiation positive regulation of cell differentiation positive regulation of endothelial cell differentiation regulation of osteoblast differentiation positive regulation of osteoblast differentiation regulation of osteoclast differentiation negative regulation of osteoclast differentiation positive regulation of fibroblast growth factor receptor signaling pathway regulation of angiogenesis positive regulation of angiogenesis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of mitotic cell cycle, embryonic regulation of fibroblast proliferation cell maturation synaptic vesicle transport animal organ development thymus development embryonic organ development oocyte development embryonic foregut morphogenesis positive regulation of skeletal muscle tissue development regulation of smooth muscle cell proliferation neuron fate determination oligodendrocyte differentiation negative regulation of oligodendrocyte differentiation regulation of neurogenesis negative regulation of neurogenesis synapse organization detection of mechanical stimulus smooth muscle cell differentiation myoblast proliferation regulation of timing of anagen regulation of synapse assembly oviduct development canonical Wnt signaling pathway limb development mesenchymal to epithelial transition trachea morphogenesis trachea formation epithelial tube branching involved in lung morphogenesis lung cell differentiation lung-associated mesenchyme development lung epithelial cell differentiation lung induction epithelial cell differentiation involved in prostate gland development epithelial cell proliferation involved in prostate gland development positive regulation of epithelial cell proliferation involved in prostate gland development hair follicle placode formation establishment of blood-brain barrier mesenchymal cell proliferation involved in lung development positive regulation of branching involved in lung morphogenesis endothelial tube morphogenesis fungiform papilla formation sympathetic ganglion development cranial ganglion development regulation of centromeric sister chromatid cohesion cellular response to growth factor stimulus cellular response to indole-3-methanol renal vesicle formation renal inner medulla development renal outer medulla development nephron tubule formation stem cell proliferation regulation of nephron tubule epithelial cell differentiation mesenchymal stem cell differentiation negative regulation of canonical Wnt signaling pathway regulation of calcium ion import acinar cell differentiation synaptic vesicle clustering apoptotic signaling pathway cell-cell adhesion positive regulation of odontoblast differentiation negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway cranial skeletal system development midbrain dopaminergic neuron differentiation positive regulation of blood vessel branching neuron projection extension embryonic brain development dorsal root ganglion development establishment of blood-retinal barrier regulation of protein localization to cell surface positive regulation of determination of dorsal identity positive regulation of neural precursor cell proliferation positive regulation of myoblast proliferation positive regulation of stem cell proliferation negative regulation of apoptotic signaling pathway
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