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Invitrogen
beta Dystroglycan Polyclonal Antibody
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FIGURE: 1 / 3
beta Dystroglycan Antibody (PA5-19731) in WB
Western blot was performed using Anti-beta Dystroglycan Polyclonal Antibody (Product # PA5-19731) and a 40 kDa band corresponding to beta dystroglycan was observed across cell lines tested. Whole cell extracts (30 µg lysate) of A-431 (Lane 1), T-47D (Lane 2), MCF7 (Lane 3), SK-BR-3 (Lane 4), A549 (Lane 5), U-2 OS (Lane 6), NTERA-2 cl.D1 (Lane 7), Caco-2 (Lane 8) and Hep G2 (Lane 9) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Pro... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-19731
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 650 - 750 of Human Dystroglycan precursor.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.9 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with mouse, rabbit, cow and dog based on sequence homology.
Target Information
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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