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Invitrogen
c-Jun Recombinant Rabbit Monoclonal Antibody (c-Jun-Clone 132)
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c-Jun Antibody (704993) in WB
Western blot was performed using c-Jun Recombinant Rabbit Monoclonal Antibody (c-Jun-Clone 132) (Product # 704993) and ~40 kDa band corresponding to c-Jun was observed across cell lines tested. Modified whole cell extracts (1% SDS) (20 µg lysate) of HEK-293 (Lane 1), HeLa (Lane 2), U-87 MG (Lane 3), U-2 OS (Lane 4) and BT-549 (Lane 5) were electrophoresed using NuPAGE™ Novex™ 4-12% Bis-Tris Protein Gels (Product # NP0321BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB33001) by iBlot™3 Western Blot ... View More
产品信息
704993
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
c-Jun-Clone 132
抗原
Protein corresponding to human c-Jun [aa231-aa310]
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
Recombinant Rabbit monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency.
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
靶标信息
c-Jun is a transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Activator protein 1; AP1; cjun; enhancer-binding protein AP1; JUN; Jun activation domain binding protein; jun oncogene; JUND; p39; Proto-oncogene c-Jun; proto-oncogene cJun; transcription factor AP-1; Transcription factor AP-1 subunit Jun; Transcription factor Jun; V-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog
基因别名: AP-1; AP1; c-Jun; cJUN; JUN; p39
UniProt ID: (Human) P05412
Entrez Gene ID: (Human) 3725
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
RNA binding
GTPase activator activity
protein binding
enzyme binding
ubiquitin protein ligase binding
cAMP response element binding
identical protein binding
ubiquitin-like protein ligase binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
R-SMAD binding
general transcription initiation factor binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
microglial cell activation
liver development
positive regulation of endothelial cell proliferation
outflow tract morphogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
apoptotic process
transforming growth factor beta receptor signaling pathway
JNK cascade
cell proliferation
negative regulation of cell proliferation
response to xenobiotic stimulus
positive regulation of epithelial cell migration
release from viral latency
monocyte differentiation
axon regeneration
response to endoplasmic reticulum stress
leading edge cell differentiation
response to muscle stretch
regulation of cell proliferation
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of DNA binding
negative regulation of neuron apoptotic process
negative regulation by host of viral transcription
positive regulation by host of viral transcription
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
response to steroid hormone
regulation of cell cycle
SMAD protein signal transduction
eyelid development in camera-type eye
positive regulation of ERK1 and ERK2 cascade
cellular response to calcium ion
cellular response to anisomycin
integrated stress response signaling
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of vascular smooth muscle cell proliferation
positive regulation of DNA-templated transcription, initiation
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