Invitrogen

c-Kit Monoclonal Antibody (ACK4)

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7 篇参考文献
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c-Kit Monoclonal Antibody (ACK4)

产品信息

MA1-70079

应用
建议稀释比
已发表文章

免疫印迹 (WB)

Assay-dependent
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免疫组化 (IHC)

Assay-dependent
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免疫细胞化学 (ICC/IF)

Assay-dependent
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流式细胞分析 (Flow)

0.2 µg/1x10^6 cells
-

酶联免疫吸附实验 (ELISA)

Assay-dependent
-

免疫沉淀 (IP)

Assay-dependent
-

中和实验 (Neu)

-
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其他PubMed (Misc)

-
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产品规格

种属反应

Mouse

已发表种属

C. elegans, Mouse

宿主/亚型

Rat / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

ACK4

抗原

IL-3 dependent mast cells derived from WB- +/+ mice
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2249527

靶标信息

KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: belly-spot; c-kit proto-oncogene protein; CD117; ckit; dominant spotting; Dominant white spotting; Mast/stem cell growth factor receptor Kit; Proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCFR; spotted sterile male; Steel Factor Receptor; Tyrosine-protein kinase Kit

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基因别名: Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; Kit; SCO1; SCO5; Sl; SOW3; Ssm; Tr-kit; W

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UniProt ID: (Mouse) P05532

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Entrez Gene ID: (Mouse) 16590

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功能
nucleotide binding protease binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity stem cell factor receptor activity protein binding ATP binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups cytokine binding protein homodimerization activity metal ion binding transmembrane signal receptor
参与通路
activation of MAPK activity ovarian follicle development myeloid progenitor cell differentiation lymphoid progenitor cell differentiation immature B cell differentiation dendritic cell cytokine production mast cell chemotaxis myeloid leukocyte differentiation protein phosphorylation glycosphingolipid metabolic process chemotaxis inflammatory response transmembrane receptor protein tyrosine kinase signaling pathway germ cell development spermatogenesis spermatid development positive regulation of cell proliferation germ cell migration regulation of cell shape visual learning response to radiation positive regulation of gene expression phosphorylation peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway lamellipodium assembly hemopoiesis cell differentiation T cell differentiation erythrocyte differentiation melanocyte differentiation positive regulation of cell migration positive regulation of pseudopodium assembly actin cytoskeleton reorganization mast cell cytokine production somatic stem cell population maintenance embryonic hemopoiesis ectopic germ cell programmed cell death intracellular signal transduction megakaryocyte development Fc receptor signaling pathway Kit signaling pathway erythropoietin-mediated signaling pathway positive regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of tyrosine phosphorylation of Stat5 protein negative regulation of programmed cell death mast cell degranulation positive regulation of MAP kinase activity positive regulation of MAPK cascade pigmentation positive regulation of Notch signaling pathway positive regulation of JAK-STAT cascade protein autophosphorylation developmental pigmentation regulation of developmental pigmentation somatic stem cell division positive regulation of long-term neuronal synaptic plasticity digestive tract development stem cell differentiation epithelial cell proliferation detection of mechanical stimulus involved in sensory perception of sound positive regulation of sequence-specific DNA binding transcription factor activity cell chemotaxis mast cell differentiation cellular response to thyroid hormone stimulus melanocyte migration melanocyte adhesion
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