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Invitrogen
c-Kit (D816V Mutant) Polyclonal Antibody
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c-Kit (D816V Mutant) Antibody (PA5-143384) in WB
Western blot analysis of c-Kit (D816V Mutant) in non-transfected (–) and transfected (+) 293T whole cell extracts (50 µg) separated by 5% SDS-PAGE. Membrane was blotted with c-Kit (D816V Mutant) Polyclonal antibody (Product # PA5-143384) using a dilution of 1:500 followed by HRP-conjugated anti-rabbit IgG secondary antibody.
产品信息
PA5-143384
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide surrounding mutant D816V of human c-Kit. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.43 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.025% Proclin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
靶标信息
This gene encodes the human homolog of the proto-oncogene c-kit|C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit|This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor)|Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism|Multiple transcript variants encoding different isoforms have been found for this gene
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-Kit; casein kinase 1, alpha 1; casein kinase 1, alpha 1-like; casein kinase I alpha S-like; Casein kinase I isoform alpha; Casein kinase I isoform alpha-like; CASP-1; CASP1 nirs variant 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); Caspase-1; CD117; CK1; CKI-alpha; CKI-alpha-like; clock regulator kinase; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1B-convertase; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; KIT proto-oncogene, receptor tyrosine kinase; MASTC; p45; PBT; SCFR
基因别名: CASP1; CK1; CK1a; CKIa; CSNK1A1; CSNK1A1L; HEL-S-77p; HLCDGP1; ICE; IL1BC; IL1BCE; P45; PRO2975
UniProt ID: (Human) P29466, (Human) P48729, (Human) Q8N752
Entrez Gene ID: (Human) 834, (Human) 1452, (Human) 122011
endopeptidase activity
cysteine-type endopeptidase activity
protein binding
cysteine-type endopeptidase activator activity involved in apoptotic process
cysteine-type endopeptidase activity involved in apoptotic process
protein kinase activity
protein serine/threonine kinase activity
ATP binding
kinase activity
protease
non-receptor serine/threonine protein kinase
response to hypoxia
proteolysis
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
regulation of autophagy
protein processing
response to lipopolysaccharide
interleukin-1 beta production
response to ATP
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
regulation of inflammatory response
mitochondrial depolarization
membrane hyperpolarization
pyroptosis
cellular response to mechanical stimulus
cellular response to organic substance
programmed necrotic cell death
toxin transport
protein phosphorylation
phagocytosis
Golgi organization
mitotic nuclear division
cell surface receptor signaling pathway
regulation of cell shape
Wnt signaling pathway
peptidyl-serine phosphorylation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
intermediate filament cytoskeleton organization
cell division
negative regulation of canonical Wnt signaling pathway
regulation of GTP binding
beta-catenin destruction complex assembly
beta-catenin destruction complex disassembly
cell morphogenesis
