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Invitrogen
c-MAF Recombinant Rabbit Monoclonal Antibody (2E3)
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c-MAF Antibody (MA573394) in IHC (P)
Immunohistochemistry analysis of c-MAF on paraffin-embedded Human Tonsil tissue. Antigen retrieval by boiling in sodium citrate buffer (pH 6.0) for 15 min. Samples were incubated with c-MAF Recombinant Monoclonal (Product # MA573394) using a dilution at 1:200 overnight at 4°C. Followed by DAB staining.
产品信息
MA573394
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2E3
抗原
KLH conjugated synthetic peptide derived from human c Maf.
偶联物
形式
Liquid
浓度
0.3 mg/mL
规格
30 µg
纯化类型
Protein A
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
c-maf is the cellular counterpart of oncogenic v-maf that belongs to the family of basic region leucine zipper domain transcription factors. The leucine-zipper domain is involved in the interaction with LRPICD. There are two forms of human c-maf mRNA, c-maf-long and c-maf-short. It is identified in the genome of the acute transforming avian retrovirus AS42. c-maf targets are IL-4 in Th2 cells, the crystalline genes in lens fiber cells, insulin gene in islet, p53 and L7 where it exerts its transcriptional role through binding to a Maf recognition element (MARE). It regulates Th2 differentiation and lineage-specific hematopoiesis. c-maf is a transcription factor for IL-10 gene expression in LPS-activated macrophages. Chromosomal aberration involving maf is found in some forms of multiple myeloma. It is expressed in myeloma cell lines and resting monocytes/macrophages.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene; b-zip transcription factor; bZIP Maf transcription factor; C-Maf; c-Maf long form; c-maf proto-oncogene; MGC71685; Proto-oncogene c-Maf; T lymphocyte c-maf long form; Transcription factor Maf; Transcription factor Maf-2; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog; V-maf musculoaponeurotic fibrosarcoma oncogene homolog
基因别名: 2810401A20Rik; A230108G15Rik; AW047063; AYGRP; c-MAF; CCA4; cMaf; CTRCT21; MAF; Maf2
UniProt ID: (Human) O75444, (Rat) P54844, (Mouse) P54843
Entrez Gene ID: (Human) 4094, (Rat) 54267, (Mouse) 17132
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
identical protein binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
double-stranded DNA binding
protein homodimerization activity
protein heterodimerization activity
basic leucine zipper transcription factor
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
lens development in camera-type eye
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
response to nutrient
gene expression
positive regulation of gene expression
megakaryocyte differentiation
regulation of chondrocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
cell development
inner ear development
lens fiber cell differentiation
integrated stress response signaling
cytokine production
transcription, DNA-templated
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