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Bethyl Laboratories
c-Maf Polyclonal Antibody
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c-Maf Antibody (A300-613A) in WB
Detection of mouse cMaf by western blot. Samples: Nuclear extract (6 µg) from HeLa cells transfected with empty vector or expression constructs for mouse MafA, mouse MafB or mouse cMaf. Antibodies: Affinity purified rabbit anti-cMaf antibody (Product # A300-613A) (lot A300-613A-2) used at 0.4 µg/mL. Detection: Chemiluminescence.
产品信息
A300-613A
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 150 and 200 of mouse v-maf musculoaponeurotic fibrosarcoma oncogene homolog (c-Maf).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
phosphate/tris citrate, pH 7-8
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Bovine
靶标信息
c-maf is the cellular counterpart of oncogenic v-maf that belongs to the family of basic region leucine zipper domain transcription factors. The leucine-zipper domain is involved in the interaction with LRPICD. There are two forms of human c-maf mRNA, c-maf-long and c-maf-short. It is identified in the genome of the acute transforming avian retrovirus AS42. c-maf targets are IL-4 in Th2 cells, the crystalline genes in lens fiber cells, insulin gene in islet, p53 and L7 where it exerts its transcriptional role through binding to a Maf recognition element (MARE). It regulates Th2 differentiation and lineage-specific hematopoiesis. c-maf is a transcription factor for IL-10 gene expression in LPS-activated macrophages. Chromosomal aberration involving maf is found in some forms of multiple myeloma. It is expressed in myeloma cell lines and resting monocytes/macrophages.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: c-Maf long form; MGC71685; Proto-oncogene c-Maf; Transcription factor Maf; V-maf musculoaponeurotic fibrosarcoma oncogene homolog
基因别名: 2810401A20Rik; A230108G15Rik; AW047063; c-maf; Maf; Maf2
UniProt ID: (Mouse) P54843
Entrez Gene ID: (Mouse) 17132
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein homodimerization activity
sequence-specific DNA binding
protein heterodimerization activity
basic leucine zipper transcription factor
negative regulation of transcription from RNA polymerase II promoter
cytokine production
lens development in camera-type eye
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
positive regulation of gene expression
regulation of chondrocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
cell development
inner ear development
lens fiber cell differentiation
