Invitrogen

cIAP1 Polyclonal Antibody

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说明书
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cIAP1 Polyclonal Antibody

产品信息

PA5-87514

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
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免疫组化（石蜡） (IHC (P))

1:50-1:200
-

免疫细胞化学 (ICC/IF)

1:50-1:100
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein (or fragment)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.11 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2804214

产品详细信息

Positive Samples: HepG2, Mouse heart, Mouse spleen, Rat brain; Cellular Location: Cytoplasm, Nucleus

Immunogen sequence: PRCEFLIRMK GQEFVDEIQG RYPHLLEQLL STSDTTGEEN ADPPIIHFGP GESSSEDAVM MNTPVVKSAL EMGFNRDLVK QTVQSKILTT

靶标信息

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: apoptosis inhibitor 1; apoptosis inhibitor 2; baculoviral IAP repeat-containing 2; Baculoviral IAP repeat-containing protein 2; C-IAP1; Cellular inhibitor of apoptosis 1; hIAP-2; IAP homolog B; IAP-2; inhibitor of apoptosis protein; Inhibitor of apoptosis protein 2; NFR2-TRAF signalling complex protein; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; TNFR2-TRAF-signaling complex protein 2

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基因别名: API1; Api2; BIRC2; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB; rIAP1; RNF48

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UniProt ID: (Human) Q13490

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Entrez Gene ID: (Human) 329, (Rat) 60371

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功能
transcription coactivator activity ubiquitin-protein transferase activity protein binding zinc ion binding transferase activity ligase activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process protein N-terminus binding molecular_function protease inhibitor
参与通路
protein polyubiquitination response to hypoxia placenta development transcription, DNA-templated regulation of transcription, DNA-templated cellular component disassembly involved in execution phase of apoptosis cell surface receptor signaling pathway I-kappaB kinase/NF-kappaB signaling regulation of tumor necrosis factor-mediated signaling pathway regulation of necrotic cell death tumor necrosis factor-mediated signaling pathway regulation of toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway NIK/NF-kappaB signaling regulation of RIG-I signaling pathway regulation of cell proliferation regulation of apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process regulation of innate immune response response to ethanol regulation of cell differentiation regulation of inflammatory response protein heterooligomerization response to cAMP regulation of cell cycle regulation of necroptotic process necroptotic process regulation of nucleotide-binding oligomerization domain containing signaling pathway mitotic spindle assembly negative regulation of ripoptosome assembly involved in necroptotic process positive regulation of protein K63-linked ubiquitination positive regulation of protein K48-linked ubiquitination positive regulation of protein monoubiquitination inhibition of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity regulation of reactive oxygen species metabolic process response to organonitrogen compound response to organic cyclic compound protein ubiquitination negative regulation of necroptotic process regulation of nucleic acid-templated transcription
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