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cIAP1 Polyclonal Antibody

查看其他20个cIAP1抗体

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cIAP1 Polyclonal Antibody

产品信息

PA5-95497

应用
建议稀释比
已发表文章

免疫印迹 (WB)

0.1-0.5 µg/mL
-

免疫细胞化学 (ICC/IF)

2 µg/mL
-

流式细胞分析 (Flow)

1-3 µg/1x10^6 cells
-

酶联免疫吸附实验 (ELISA)

0.1-0.5 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

E.coli-derived human cIAP1 recombinant protein (Position: D320-T570).
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

规格

100 µg

纯化类型

Affinity chromatography

保存液

PBS with 4mg trehalose

内含物

0.05mg sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2807299

产品详细信息

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human Hela whole cell, human Jurkat whole cell, human MCF-7 whole cell, human COLO-320 whole cell, human U-87MG whole cell, human A549 whole cell, rat thymus tissue, mouse thymus tissue, mouse testis tissue. ICC/IF: U20S cell. Flow: U20S cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

靶标信息

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: apoptosis inhibitor 1; apoptosis inhibitor 2; baculoviral IAP repeat-containing 3; Baculoviral IAP repeat-containing protein 2; C-IAP1; Cellular inhibitor of apoptosis 1; hIAP-2; IAP homolog B; IAP-2; inhibitor of apoptosis protein; Inhibitor of apoptosis protein 2; mIAP-2; mIAP2; NFR2-TRAF signalling complex protein; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; TNFR2-TRAF-signaling complex protein 2; unnamed protein product

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基因别名: API1; Api2; AW146227; BIRC2; Birc3; c-IAP1; cIAP1; cIAP2; Hiap-2; HIAP1; HIAP2; IAP-2; IAP1; IAP2; mcIAP1; MIAP1; MIAP2; MIHB; MIHC; rIAP1; RNF48

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UniProt ID: (Mouse) Q62210

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Entrez Gene ID: (Human) 329, (Mouse) 11797, (Rat) 60371

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功能
transcription coactivator activity ubiquitin-protein transferase activity protein binding zinc ion binding transferase activity identical protein binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process ubiquitin binding macromolecular complex binding chaperone binding ubiquitin protein ligase activity FBXO family protein binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein N-terminus binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity molecular_function protease inhibitor
参与通路
protein polyubiquitination response to hypoxia inflammatory response cell surface receptor signaling pathway I-kappaB kinase/NF-kappaB signaling extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of protein ubiquitination tumor necrosis factor-mediated signaling pathway regulation of toll-like receptor signaling pathway NIK/NF-kappaB signaling regulation of RIG-I signaling pathway regulation of cell proliferation regulation of apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process regulation of innate immune response response to ethanol regulation of cell differentiation positive regulation of transcription, DNA-templated regulation of inflammatory response response to cAMP regulation of cell cycle regulation of necroptotic process negative regulation of necroptotic process necroptotic process regulation of nucleotide-binding oligomerization domain containing signaling pathway positive regulation of protein K63-linked ubiquitination positive regulation of protein K48-linked ubiquitination positive regulation of protein monoubiquitination response to bleomycin placenta development transcription, DNA-templated regulation of transcription, DNA-templated apoptotic process protein ubiquitination protein heterooligomerization negative regulation of ripoptosome assembly involved in necroptotic process regulation of nucleic acid-templated transcription inhibition of cysteine-type endopeptidase activity involved in apoptotic process regulation of reactive oxygen species metabolic process response to organonitrogen compound response to organic cyclic compound mitotic spindle assembly
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