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Suggested positive control: Hela whole cell lysate; Jurkat whole cell lysate.
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: AIP 2; API2; Apoptosis inhibitor 2; baculoviral IAP repeat-containing 3; Baculoviral IAP repeat-containing protein 3; C-IAP2; Cellular inhibitor of apoptosis 2; H HIAP1; H MALT2; hIAP-1; IAP homolog; IAP homolog C; IAP-1; Inhibitor of apoptosis protein 1; mammalian IAP homolog C; RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1
基因别名: AIP1; API2; BIRC3; c-IAP2; CIAP2; HAIP1; HIAP1; MALT2; MIHC; RNF49
UniProt ID: (Human) Q13489
Entrez Gene ID: (Human) 330