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Invitrogen
eIF4A3 Recombinant Rabbit Monoclonal Antibody (17H5L19)
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eIF4A3 Antibody (702545) in ICC/IF
For immunofluorescence analysis, HeLa cells were fixed and permeabilized for detection of endogenous eIF4A3 using Anti-eIF4A3 Recombinant Rabbit Monoclonal Antibody (Product # 702545, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of eIF4A3 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S3... View More
产品信息
702545
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
17H5L19
抗原
Peptides corresponding to human eIF4A3 (aa 15-33, 302-318)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with Monkey, Rat, Sheep, Pig, Bovine
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
eIF4A3 is a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. eIF4A3 is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD (Asp-Glu-Ala-Asp) box polypeptide 48; DEAD box protein 48; eIF-4A-III; eIF4A-III; Eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-like NUK-34; Eukaryotic translation initiation factor 4A isoform 3; eukaryotic translation initiation factor 4A, isoform 3; hNMP 265; NMP 265; Nuclear matrix protein 265
基因别名: 2400003O03Rik; DDX48; eIF4A-III; EIF4A3; eIF4AIII; KIAA0111; mKIAA0111; MUK34; NMP265; NUK34; RCPS
UniProt ID: (Human) P38919, (Mouse) Q91VC3
Entrez Gene ID: (Human) 9775, (Mouse) 192170
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
nuclear-transcribed mRNA poly(A) tail shortening
mRNA splicing, via spliceosome
rRNA processing
termination of RNA polymerase II transcription
RNA export from nucleus
mRNA export from nucleus
associative learning
RNA splicing
RNA secondary structure unwinding
response to organic cyclic compound
selenocysteine metabolic process
negative regulation of translation
mRNA 3'-end processing
exploration behavior
positive regulation of translation
embryonic cranial skeleton morphogenesis
cellular response to selenite ion
negative regulation of excitatory postsynaptic potential
negative regulation of selenocysteine incorporation
negative regulation of selenocysteine insertion sequence binding
cellular response to brain-derived neurotrophic factor stimulus
positive regulation of transcription from RNA polymerase II promoter
positive regulation of mRNA splicing, via spliceosome
