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Invitrogen
eIF5A Recombinant Rabbit Monoclonal Antibody (25GB2900)
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图: 1 / 4
eIF5A Antibody (MA571069) in ICC/IF
Immunocytochemistry analysis of eIF5A in HepG2 cells. Sample was incubated with eIF5A monoclonal antibody (Product # MA571069) at a dilution of 1:1,000. Nuclei were stained blue with DAPI and Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar, 20 μm.
产品信息
MA571069
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
25GB2900
抗原
A synthesized peptide derived from human (1-47) eIF5A.
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Dry ice (international)
靶标信息
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of TP53/p53 and TP53/p53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: eIF-4D; eIF-5A; eIF-5A-1; eIF-5A1; eukaryotic initiation factor 5A; Eukaryotic initiation factor 5A isoform 1; Eukaryotic translation initiation factor 5A-1; MGC104255; MGC99547; OTTHUMP00000128384; Rev-binding factor; uORF A
基因别名: AA410058; D19Wsu54e; eIF-4D; EIF-5A; eIF-5A-1; eIF-5A1; Eif4d; EIF5A; EIF5A1; eIF5AI
UniProt ID: (Human) P63241, (Mouse) P63242, (Rat) Q3T1J1
Entrez Gene ID: (Human) 1984, (Mouse) 276770, (Rat) 287444
mRNA export from nucleus
translational frameshifting
protein export from nucleus
nucleocytoplasmic transport
apoptotic process
positive regulation of cell proliferation
peptidyl-lysine modification to peptidyl-hypusine
positive regulation of translational elongation
positive regulation of translational termination
translation
translational elongation
transport
protein transport
positive regulation of apoptotic process
negative regulation of apoptotic process
mRNA transport
positive regulation of muscle cell differentiation
aging
