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Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding two different isoforms have been found for this gene.
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蛋白别名: B(2)GCN homolog; B4 integrin interactor; CAB; eIF-6; eIF-6 {ECO:0000255|HAMAP-Rule:MF_03132}; EIF6; eukaryotic translation initiation factor 3A; Eukaryotic translation initiation factor 6; eukaryotic translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_03132}; integrin beta 4 binding protein; p27 beta-4 integrin-binding protein; p27(BBP)
基因别名: 1110004P11; AA408895; b(2)gcn; CAB; eIF-6; EIF3A; EIF6; imc-415; ITGB4BP; OK/SW-cl.27; p27(BBP); p27BBP
UniProt ID: (Human) P56537, (Rat) Q3KRD8, (Mouse) O55135
Entrez Gene ID: (Human) 3692, (Rat) 305506, (Mouse) 16418