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Recommended positive controls: A431, H1299, HeLa, HepG2, Raji, NCI-H929, mouse brain.
Predicted reactivity: Mouse (100%), Rat (99%), Zebrafish (87%), Xenopus laevis (91%), Chicken (96%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Heterogeneous nuclear ribonucleoprotein H; hnRNP H
基因别名: AI642080; E430005G16Rik; Hnrnph; HNRNPH1; HNRPH; HNRPH1
UniProt ID: (Human) P31943, (Mouse) O35737
Entrez Gene ID: (Human) 3187, (Mouse) 59013
分子生物学功能: RNA splicing factor