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Invitrogen
hu14.18-IL2 Humanized Biosimilar Recombinant Human Monoclonal Antibody
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产品信息
MA5-59449
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term EMD 273063.
靶标信息
Hu14.18-IL2 is a humanized monoclonal antibody covalently linked to two interleukin-2 (IL-2) molecules. The hu14.18 component specifically targets GD2, a disialoganglioside abundantly expressed on tumor cells, especially in neuroblastoma and melanoma. Meanwhile, IL-2 stimulates the proliferation and activation of immune cells such as natural killer (NK) cells and T cells. GD2, also known as GD2 ganglioside, is a tumor-associated glycolipid antigen that is overexpressed in a variety of cancers, particularly those derived from neuroectodermal tissues. Structurally, GD2 contains three carbohydrate residues and two sialic acids bonded to a ceramide tail, which is embedded in the outer plasma membrane. This compound plays a critical role in cell surface glycosylation changes during malignant transformation and is ranked high as a target for cancer vaccine development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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