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mGluR1/mGluR5 Monoclonal Antibody (N75/33), PerCP

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mGluR1/mGluR5 Monoclonal Antibody (N75/33), PerCP

产品信息

MA5-45552

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫组化 (IHC)

1:1,000
-

免疫细胞化学 (ICC/IF)

1:100
-

免疫沉淀 (IP)

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

N75/33

抗原

Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b
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偶联物

PerCP PerCP PerCP

激发/发射光谱

482/675 nm 查看光谱 spectra

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA

内含物

no preservative

保存条件

4°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2932006

产品详细信息

1 µg/mL of MA5-45552 was sufficient for detection of mGluR1/5 glutamate receptor in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 130kDa (both mGluR1 and mGluR5).

This antibody was formerly sold as clone S75-33.

靶标信息

may play a role in synaptic transmission; may interact with mGluR1, another group I metabotropic glutamate receptor.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

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引用该产品

生物信息学

蛋白别名: G protein coupled receptor family C group 1 member A; G protein coupled receptor, family C, group 1, member A; G protein coupled receptor, family C, group 1, member E; G protein-coupled receptor GRM5; G protein-coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member E; glutamate receptor; glutamate receptor, metabotropic 1; glutamate receptor, metabotropic 5; GPCR family C; metabotropic glutamate receptor (mGluR5); Metabotropic glutamate receptor 1; Metabotropic glutamate receptor 5; metabotropic glutamate receptor 5b; metabotropic glutamate receptor subtype 5 homolog; metabotropic glutamate receptor subtype 5b; metabotropic glutamate receptor type 5; mGluR1; mGluR5; mGluR5f; mGluR5g; mGluR5h; mGluR5i; mGlurR1a; protein phosphatase 1, regulatory subunit 85; protein phosphatase 1, regulatory subunit 86; unnamed protein product

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基因别名: 4930455H15Rik; 6430542K11Rik; AI850523; ENSMUSG00000075319; Glu5R; Gm10828; GPRC1A; GPRC1E; GRM1; GRM5; MGLU1; mGlu5; MGLUR1; MGLUR5; mGluR5b; nmf373; PPP1R85; PPP1R86; rcw; SCA44; SCAR13; wobl

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UniProt ID: (Human) Q13255, (Human) P41594, (Mouse) P97772, (Rat) P23385, (Rat) P31424, (Mouse) Q3UVX5

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Entrez Gene ID: (Human) 2911, (Human) 2915, (Mouse) 14816, (Rat) 24414, (Rat) 24418, (Mouse) 108071

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功能
adenylate cyclase inhibiting G-protein coupled glutamate receptor activity G-protein coupled receptor activity protein binding glutamate receptor activity G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration protein tyrosine kinase activator activity A2A adenosine receptor binding identical protein binding protein tyrosine kinase binding PLC activating G-protein coupled glutamate receptor activity signal transducer activity estrogen receptor binding calmodulin binding PDZ domain binding G-protein coupled receptor
参与通路
signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled glutamate receptor signaling pathway G-protein coupled glutamate receptor signaling pathway chemical synaptic transmission locomotory behavior sensory perception of pain regulation of membrane potential positive regulation of MAPK cascade regulation of sensory perception of pain regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential cellular response to electrical stimulus L-glutamate import across plasma membrane synaptic signaling via neuropeptide regulation of postsynaptic cytosolic calcium ion concentration desensitization of G-protein coupled receptor protein signaling pathway regulation of transcription, DNA-templated learning or memory learning regulation of long-term neuronal synaptic plasticity positive regulation of long-term neuronal synaptic plasticity modulation of synaptic transmission synapse organization positive regulation of calcium-mediated signaling cognition positive regulation of intracellular signal transduction cellular response to beta-amyloid activation of MAPKK activity activation of MAPK activity protein kinase C-activating G-protein coupled receptor signaling pathway calcium-mediated signaling dimeric G-protein coupled receptor signaling pathway regulation of MAPK cascade positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway regulation of glutamate secretion membrane depolarization synaptic transmission, GABAergic activation of MAPKKK activity protein phosphorylation negative regulation of locomotion phosphatidylinositol-mediated signaling
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