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Alomone Labs, LTD
mGluR5 (extracellular) Polyclonal Antibody
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mGluR5 (extracellular) Antibody (AGC-007-200UL) in ICC/IF
Expression of mGluR5 in rat GH3 pituitary cells - Cell surface detection of mGluR5 in live intact rat GH3 pituitary cells using Anti-mGluR5 (extracellular) Antibody (#AGC-007), (1:100), followed by goat- Anti-rabbit-AlexaFluor-555 secondary Antibody .
产品信息
AGC-007-200UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
EGFAQENSKYNKTC, corresponding to amino acids 367-380 of rat mGluR5, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.75 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
靶标信息
GRK1 is a member of the guanine nucleotide protein-coupled (G protein) receptor kinase subfamily of Serine/Threonine kinase family. GRK1 phosphorylates rhodopsin and initiates its deactivation. G protein mediated phosphorylation promotes the binding of arrestin, which removes the receptor from the G-protein and terminates the receptor signal chain. GRK1 is farnesylated to promote membrane association. Studies have shown that GRK1 has been shown to be inhibited by recoverin, a Calcium binding protein. Diseases associated with GRK1 protein dysfunction include Oguchi Disease-2 and Hereditary Night Blindness.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A830007B11Rik; D16Ium24; D16Ium24e; G protein coupled receptor, family C, group 1, member E; G protein-coupled receptor GRM5; G protein-coupled receptor, family C, group 1, member E; Glur-5; Glur5; Glurbeta1; glutamate receptor; glutamate receptor, metabotropic 5; GPRC1A; GRM 1; GRM 5; GRM1; GRM1 alpha; GRM1A; metabotropic 1; metabotropic glutamate receptor (mGluR5); Metabotropic glutamate receptor 5; metabotropic glutamate receptor 5b; metabotropic glutamate receptor subtype 5b; metabotropic glutamate receptor type 5; MGC25101; mGlu1; mGluR; mGluR1; mGluR1 alpha; mGluR1A; mGluR5; mGluR5a; protein phosphatase 1, regulatory subunit 86
基因别名: 6430542K11Rik; AI850523; Glu5R; GPRC1E; GRM5; mGlu5; MGLUR5; mGluR5b; PPP1R86
UniProt ID: (Human) P41594, (Rat) P31424, (Mouse) Q3UVX5
Entrez Gene ID: (Human) 2915, (Rat) 24418, (Mouse) 108071
protein kinase C-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
chemical synaptic transmission
learning
locomotory behavior
regulation of long-term neuronal synaptic plasticity
cognition
regulation of synaptic transmission, glutamatergic
activation of MAPKKK activity
desensitization of G-protein coupled receptor protein signaling pathway
regulation of transcription, DNA-templated
protein phosphorylation
negative regulation of locomotion
phosphatidylinositol-mediated signaling
positive regulation of long-term neuronal synaptic plasticity
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
signal transduction
G-protein coupled receptor signaling pathway
