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Invitrogen
mTOR Monoclonal Antibody (D7)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA565979
产品规格
种属反应
Human,
Pig,
Rat
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
D7
抗原
Recombinant Serine/threonine-protein kinase mTOR (mTOR) (Ala2226-Val2488)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
200 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
FRAP1 (mTOR) is a serine/threonine kinase that plays a critical role in cellular growth and proliferation. Perturbations in the mTOR/PI3-kinase/AKT pathway are associated with numerous forms of cancer. FRAP1 is also the target of rapamycin and its analogues, which are currently used as immunosuppressants and cancer therapeutics. Mutations affecting the gene results in Smith-Kingsmore syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FK506 binding protein 12-rapamycin associated protein 1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; m-TOR; Mammalian target of rapamycin; Mechanistic target of rapamycin; mTOR; mTORC1; Rapamycin and FKBP12 target 1; rapamycin and FKBP12 target-1 protein; Rapamycin target protein 1; RAPT1; Serine/threonine-protein kinase mTOR; Tyrosine-protein kinase mTOR
基因别名: FRAP; FRAP1; FRAP2; MTOR; RAFT1; RAPT1
UniProt ID: (Rat) P42346
Entrez Gene ID: (Pig) 100127359, (Rat) 56718
RNA polymerase III type 1 promoter DNA binding
RNA polymerase III type 2 promoter DNA binding
RNA polymerase III type 3 promoter DNA binding
TFIIIC-class transcription factor binding
protein serine/threonine kinase activity
protein binding
ATP binding
drug binding
kinase activity
protein domain specific binding
ribosome binding
protein dimerization activity
phosphoprotein binding
non-receptor serine/threonine protein kinase
protein modifying enzyme
double-strand break repair via homologous recombination
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
regulation of glycogen biosynthetic process
regulation of carbohydrate metabolic process
protein phosphorylation
germ cell development
negative regulation of autophagy
positive regulation of lamellipodium assembly
positive regulation of gene expression
positive regulation of myotube differentiation
cell growth
negative regulation of macroautophagy
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
cell projection organization
positive regulation of actin filament polymerization
ruffle organization
regulation of myelination
cellular response to nutrient levels
TOR signaling
regulation of fatty acid beta-oxidation
regulation of response to food
response to insulin
regulation of actin cytoskeleton organization
response to amino acid
regulation of carbohydrate utilization
positive regulation of translation
negative regulation of cell size
regulation of protein kinase activity
positive regulation of transcription from RNA polymerase III promoter
protein autophosphorylation
positive regulation of lipid biosynthetic process
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of stress fiber assembly
negative regulation of NFAT protein import into nucleus
positive regulation of protein kinase B signaling
cellular response to hypoxia
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