Invitrogen

n-Myc Polyclonal Antibody

Name: n-Myc Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-17403
Price: 4368.00 CNY
Availability: InStock

高级验证

1个已发表图片

3 篇参考文献

查看其他17个n-Myc抗体

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

Additional Information:

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n-Myc Antibody (PA5-17403) in WB

Western blot analysis of N-Myc in extracts from HeLa cells, either mock transfected or transfected with murine N-Myc, using N-Myc polyclonal antibody (Product # PA5-17403).

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

Product Image Gallery

n-Myc Antibody — Figure 5 CD532 inhibits Aurora A kinase activity and downregulates MYCN. (A-D) SKN-BE(2) cells were treated for 6 hr with the indicated compounds at 1 muM and EdU was added 1 hr prior to harvest to measure cell cycle by EdU incorporation and propidium iodide (PI) staining (A), p-H3 (B), pan-Aurora (A, B, and C isoforms) phosphorylation (C), and MYCN protein (D) by flow cytometry. See also Figure S3 . {TM}

Immunogen image

Immunogen Image n-Myc Polyclonal Antibody

产品信息

PA5-17403

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

流式细胞分析 (Flow)

查看1篇已发表文章 1篇已发表文章

其他PubMed (Misc)

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产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to residues surrounding lysine 351 of human N-Myc

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

31.1 µg/mL

3.11 µg

纯化类型

Antigen affinity chromatography

保存液

0.01M HEPES, pH 7.5, with 0.15M NaCl, 50% glycerol, 100µg/mL BSA

内含物

no preservative

保存条件

-20°C

Ambient (domestic); Wet ice (international)

AB_10988360

产品详细信息

It is not recommended to aliquot this antibody.

This antibody is not cross-reactive with other Myc family members.

靶标信息

N-Myc protein is member of the MYC family of transcription factor proteins with a basic helix-loop-helix (bHLH) domain. N-Myc is similarly regulated and functionally complementary to C-Myc in the context of various cellular growth and differentiation processes. MYCN gene is considered the hallmark of neuroblastoma, amplification and overexpression of the MYCN proto-oncogene occurs in approximately 20% of neuroblastomas and is associated with advanced stage disease, rapid tumor progression, and poor prognosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: class E basic helix-loop-helix protein 37; neuroblastoma MYC oncogene; neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene; oncogene NMYC; oncogene pp65/67; unnamed protein product; v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog

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基因别名: bHLHe37; FGLDS1; MODED; MPAPA; MYCNsORF; MYCNsPEP; N-myc; NMYC; ODED

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UniProt ID: (Human) P04198

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Entrez Gene ID: (Human) 4613

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功能

RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding kinase binding protein dimerization activity sequence-specific double-stranded DNA binding

参与通路

regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter positive regulation of gene expression negative regulation of gene expression positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of reactive oxygen species metabolic process