Search
Invitrogen
p19ARF Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA1-30670
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide conjugated to KLH, derived from a sequence within residues 50-150 of mouse p19ARF..
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
tris citrate/tris phosphate, pH 7.0-8.0
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-30670 recognizes p19ARF, Uniprot ID Q64364.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
In humans, the multiple tumor suppressor 1 locus (MTS1) encodes two unrelated genes, p16INK4a and p19ARF. Although both act as cell proliferation inhibitors, their mechanisms of action are different. p19ARF works as part of a p53-dependent pathway to counter uncontrolled proliferation and oncogenic signals. Mice lacking the p19ARF gene rapidly develop a broad spectrum of tumors. This result indicates that p19ARF is an important tumor suppressor. In addition, p19ARF helps prevent transforming signals from various onocoproteins via the p53 regulatory loop. These studies and others display the importance of p19ARF in cell cycle control and tumor suppression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: a frameshift between exon 1 (0.18) and exon 2 changed the ORF of p16INK4 gene.; alternative reading frame; autophagy inducer; CDK4 inhibitor p16-INK4; CDK4I; CDKN2A/ARF Intron 2 lncRNA; cell cycle inhibitor; cell cycle negative regulator beta; cell cycle regulator; Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); alternatively spliced; cyclin-dependent kinase inhibitor 2a p16Ink4a; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor protein; hypothetical 18.1 kDa protein from longest open reading frame; inhibitor of cdk4 A; mitochondrial smARF; multiple tumor suppressor 1; multiple tumour suppressor 1; p16; p16 gamma; p16-INK4; p16-INK4a; p16ink4a; unnamed protein product
基因别名:
ARF; ARF-INK4a; CAI2; CDK4I; CDKN2; CMM2; INK4; INK4A; INK4a-ARF; Ink4a/Arf; MLM; MTS-1; MTS1; P14; P14ARF; P16; p16(INK4a); P16-INK4A; p16Cdkn2a; P16INK4; P16INK4A; P19; p19
UniProt ID: (Human) P42771, (Rat) Q9R0Z3, (Mouse) P51480
Entrez Gene ID: (Human) 1029, (Rat) 25163, (Mouse) 12578
p53 binding
RNA binding
cyclin-dependent protein serine/threonine kinase inhibitor activity
protein binding
SUMO transferase activity
protein kinase binding
NF-kappaB binding
ligase inhibitor activity
ubiquitin-protein transferase inhibitor activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
MDM2/MDM4 family protein binding
disordered domain specific binding
ubiquitin ligase inhibitor activity
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA-binding transcription factor binding
regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of transcription from RNA polymerase II promoter
protein polyubiquitination
mitophagy
negative regulation of cell-matrix adhesion
apoptotic process
Ras protein signal transduction
negative regulation of cell proliferation
epidermis development
rRNA transcription
response to xenobiotic stimulus
response to salt stress
regulation of gene expression
cerebellum development
neurogenesis
keratinocyte differentiation
negative regulation of cell growth
nuclear body organization
negative regulation of B cell proliferation
regulation of protein stability
protein destabilization
negative regulation of immature T cell proliferation in thymus
positive regulation of protein sumoylation
negative regulation of mammary gland epithelial cell proliferation
positive regulation of smooth muscle cell apoptotic process
protein localization to nucleus
somatic stem cell population maintenance
negative regulation of protein catabolic process
glucose homeostasis
positive regulation of apoptotic process
positive regulation of DNA damage response, signal transduction by p53 class mediator
keratinocyte proliferation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of nucleocytoplasmic transport
regulation of protein export from nucleus
somatic stem cell division
protein stabilization
regulation of cell cycle
mitochondrial depolarization
negative regulation of protein kinase B signaling
positive regulation of apoptotic process involved in mammary gland involution
response to caloric restriction
cellular response to hydrogen peroxide
protein K63-linked ubiquitination
response to fatty acid
cellular response to glucose stimulus
cellular response to gamma radiation
negative regulation of ribosome biogenesis
cellular senescence
replicative senescence
oncogene-induced cell senescence
apoptotic signaling pathway
positive regulation of protein localization to nucleus
positive regulation of signal transduction by p53 class mediator
protein localization to nucleolus
regulation of protein localization to mitochondrion
regulation of ubiquitin protein ligase activity
negative regulation of protein localization to nucleolus
amyloid fibril formation
regulation of G1/S transition of mitotic cell cycle
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of macrophage apoptotic process
negative regulation of hepatocyte proliferation
positive regulation of gene expression
negative regulation of protein neddylation
protein sumoylation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
