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Bethyl Laboratories

p300 Polyclonal Antibody

View all (20) p300 antibodies

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p300 Polyclonal Antibody

Product Details

IHC-00028

Applications
Tested Dilution
Publications

Immunohistochemistry (IHC)

1:100-1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 950 and 1000 of human 1A-associated protein p300.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.10 mg/mL

Amount

10 µg

Purification

Antigen affinity chromatography

Storage buffer

TBS, pH 7.0 to 8.0, with 0.1% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Monkey, Gorilla, Chimpanzee and Crab-eating macaque

Target Information

EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. p300 is related by sequence to CPB (CREB-binding protein [CREB: cyclic-AMP responsive element binding protein]), and like CPB can stimulate transcription through activation of CREB. This EP300 activity is specifically inhibited by the adenovirus oncoprotein E1A. EP300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: E1A binding protein p300; E1A-associated protein p300; E1A-binding protein, 300kD; histone butyryltransferase p300; histone crotonyltransferase p300; p300 HAT; protein 2-hydroxyisobutyryltransferase p300; protein isonicotinyltransferase p300; protein lactyltransferas p300; protein propionyltransferase p300

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Gene Aliases: KAT3B; MKHK2; p300; RSTS2

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UniProt ID: (Human) Q09472

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Entrez Gene ID: (Human) 2033

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Function(s)
transcription cofactor binding transcription coactivator binding p53 binding DNA binding chromatin binding damaged DNA binding transcription cofactor activity transcription coactivator activity histone acetyltransferase activity lysine N-acetyltransferase activity, acting on acetyl phosphate as donor protein binding beta-catenin binding zinc ion binding H3 histone acetyltransferase activity H4 histone acetyltransferase activity acetyltransferase activity transferase activity, transferring acyl groups ligand-dependent nuclear receptor binding chromatin DNA binding histone acetyltransferase activity (H3-K18 specific) histone H2B acetyltransferase activity histone acetyltransferase activity (H3-K27 specific) tau protein binding androgen receptor binding NF-kappaB binding RNA polymerase II sequence-specific DNA binding transcription factor binding peptide-lysine-N-acetyltransferase activity protein propionyltransferase activity pre-mRNA intronic binding STAT family protein binding peptide 2-hydroxyisobutyryltransferase activity peptide lactyltransferase (CoA-dependent) activity histone lactyltransferase (CoA-dependent) activity acetylation-dependent protein binding peptide crotonyltransferase activity peptide butyryltransferase activity histone crotonyltransferase activity histone butyryltransferase activity histone isonicotinyltransferase activity DNA-binding transcription factor binding histone H3K122 acetyltransferase activity histone H1K75 acetyltransferase activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter response to hypoxia thigmotaxis behavioral defense response stimulatory C-type lectin receptor signaling pathway regulation of glycolytic process chromatin remodeling regulation of transcription, DNA-templated protein acetylation internal protein amino acid acetylation apoptotic process I-kappaB kinase/NF-kappaB signaling nervous system development learning or memory circadian rhythm regulation of autophagy negative regulation of autophagy regulation of mitochondrion organization positive regulation of neuron projection development internal peptidyl-lysine acetylation positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of protein complex assembly protein destabilization cellular response to nutrient levels negative regulation of protein oligomerization cellular response to UV multicellular organism growth swimming positive regulation of protein import into nucleus intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator response to estrogen positive regulation by host of viral transcription fat cell differentiation negative regulation of gluconeogenesis positive regulation of gene expression, epigenetic positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JAK-STAT cascade protein stabilization canonical Wnt signaling pathway face morphogenesis regulation of androgen receptor signaling pathway peptidyl-lysine propionylation cellular response to leucine regulation of tubulin deacetylation peptidyl-lysine crotonylation peptidyl-lysine butyrylation DNA repair-dependent chromatin remodeling regulation of cellular response to heat positive regulation of protein localization to nucleus regulation of signal transduction by p53 class mediator negative regulation of chromosome condensation negative regulation of brown fat cell differentiation positive regulation of TORC1 signaling positive regulation of TORC2 signaling positive regulation of T-helper 17 cell lineage commitment regulation of nucleotide-excision repair
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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