Search
Invitrogen
p35 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
图: 1 / 4
p35 Antibody (PA5-78263) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of p35 was performed in DIV10 rat E18 primary cortical neuron cells fixed in 4% paraformaldehyde at RT for 15 min. Green: p35 Polyclonal Antibody (Product # PA5-78263) diluted at 1:500. Red: alpha Tubulin, stained by alpha Tubulin antibody. Blue: Fluoroshield with DAPI.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-78263
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of Human p35. The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.97 mg/mL
规格
97 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: HeLa
Predicted Reactivity: Mouse (100%), Rat (100%), Bovine (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: CDK5 activator 1; Cyclin-dependent kinase 5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; cyclin-dependent kinase 5, regulatory subunit (p35) 1; p23; tau protein kinase II 23 kDa subunit; TPKII regulatory subunit
基因别名: CDK5R; CDK5R1; D11Bwg0379e; NCK5A; p25; p35
UniProt ID: (Rat) P61810, (Mouse) P61809
Entrez Gene ID: (Rat) 116671, (Mouse) 12569
cyclin-dependent protein serine/threonine kinase activity
calcium ion binding
protein binding
kinase activity
cyclin-dependent protein kinase 5 activator activity
protein kinase binding
protein serine/threonine kinase activator activity
cadherin binding
ephrin receptor binding
cytoskeletal protein binding
kinase activator
neuron migration
protein phosphorylation
neuron cell-cell adhesion
G-protein coupled acetylcholine receptor signaling pathway
axon guidance
axonal fasciculation
brain development
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
cerebellum development
superior olivary nucleus maturation
hippocampus development
cerebral cortex radially oriented cell migration
layer formation in cerebral cortex
neuron differentiation
negative regulation of axon extension
neuron projection development
regulation of actin cytoskeleton organization
serine phosphorylation of STAT3 protein
ionotropic glutamate receptor signaling pathway
positive regulation of neuron apoptotic process
positive regulation of protein kinase activity
negative regulation of transcription, DNA-templated
ephrin receptor signaling pathway
rhythmic process
axon extension
regulation of dendritic spine morphogenesis
regulation of microtubule cytoskeleton organization
positive regulation of cell cycle arrest
positive regulation of protein serine/threonine kinase activity
positive regulation of protein targeting to membrane
regulation of cell cycle
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
