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Invitrogen
p38 MAPK gamma Polyclonal Antibody
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p38 MAPK gamma Antibody (PA5-88940) in WB
Western blot was performed using Anti-p38 MAPK gamma Polyclonal Antibody (Product # PA5-88940) and a 45kDa band corresponding to Mitogen-activated protein kinase 12 was observed across in all tested cell lines and tissues except MOLT-4 and Mouse Thymus, and was upregulated upon differentiation of C2C12 to myoblast and iPSC to cardiomyocytes. Whole cell extracts (30 µg lysate) of C2C12 (Lane 1), C2C12 (differentiated to Myoblast) (Lane 2), MDA-MB-231 (Lane 3), MCF7 (Lane 4), iPSC (Lane 5), iPSC (differentiated to Cardiomyocytes) (Lane 6), H... View More
产品信息
PA5-88940
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 248-367 of human MAPK12 (NP_0029602)
偶联物
形式
Liquid
浓度
0.68 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: EFVQRLQSDE AKNYMKGLPE LEKKDFASIL TNASPLAVNL LEKMLVLDAE QRVTAGEALA HPYFESLHDT EDEPQVQKYD DSFDDVDRTL DEWKRVTYKE VLSFKPPRQL GARVSKETPL; Positive Samples: HeLa, K-562, PC-12, 22Rv1, Mouse lung, Mouse testis; Cellular Location: Cytoplasm, Mitochondrion, Nucleus
靶标信息
MAPK12 (p38 gamma) is a serine/threonine kinase involved in many different cellular processes. It is activated during hypoxia and gamma-irradiation-induced G(2) arrest. Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. MAPK12 functions as a signal transducer during differentiation of myoblasts to myotubes.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ERK-6; ERK5; Extracellular signal-regulated kinase 6; MAP kinase 12; MAP kinase p38 gamma; MAPK 12; mitogen activated protein kinase 12; Mitogen-activated protein kinase 12; mitogen-activated protein kinase 3; Mitogen-activated protein kinase p38 gamma; OTTHUMP00000196671; SAP kinase-3; stress activated protein kinase 3; Stress-activated protein kinase 3
基因别名: AW123708; ERK-6; ERK3; ERK6; MAPK 12; MAPK12; P38GAMMA; PRKM12; SAPK-3; SAPK3
UniProt ID: (Human) P53778, (Rat) Q63538, (Mouse) O08911
Entrez Gene ID: (Human) 6300, (Rat) 60352, (Mouse) 29857
magnesium ion binding
protein serine/threonine kinase activity
MAP kinase activity
protein binding
ATP binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
non-receptor serine/threonine protein kinase
MAPK cascade
transcription, DNA-templated
regulation of transcription, DNA-templated
DNA damage induced protein phosphorylation
cell cycle arrest
signal transduction
muscle organ development
positive regulation of peptidase activity
peptidyl-serine phosphorylation
myoblast differentiation
vascular endothelial growth factor receptor signaling pathway
positive regulation of muscle cell differentiation
protein phosphorylation
negative regulation of cell cycle
cell cycle
phosphorylation
