Search Thermo Fisher Scientific
图: 1 / 1
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Reactivity occurs against human p47 ING3 protein. This sequence only shows homology to isoform 1 for ING3. The sequence is not present in isoforms 2 and 3. However, 100% homology is on record for this protein from human, dog, rat, chimpanzee and orangutan. Cross reactivity with p47 ING3 protein from mouse and chicken sources is also expected based on high homology (one amino acid change in sequence) by BLAST. Reactivity with p47 ING3 proteins from other sources is not known.
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Eaf 4; FLJ20089; ING 2; ING 3; inhibitor of growth family, member 3; Inhibitor of growth protein 3; p47 p47 ING3; p47ING3; p47ING3 protein
基因别名: Eaf4; HSPC301; ING2; ING3; MEAF4; p47ING3
UniProt ID: (Human) Q9NXR8
Entrez Gene ID: (Human) 54556
分子生物学功能: chromatin/chromatin-binding, or -regulatory protein