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Invitrogen
pro-IL-33 Monoclonal Antibody (518017)
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产品信息
MA5-61510
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
518017
抗原
E. coli-derived recombinant mouse IL-33 Propeptide, Met1-Leu108
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
Pro-IL-33 is the precursor form of interleukin-33 (IL-33), a cytokine that plays an essential role in the immune system, particularly in the regulation of inflammatory and immune responses. IL-33 is a member of the IL-1 family and is produced by various cell types, including epithelial cells, endothelial cells, and fibroblasts. In its precursor form, pro-IL-33 is biologically active and can be cleaved by caspases or other proteases to generate the mature, active cytokine. IL-33 functions by binding to its receptor, ST2 (IL1RL1), on the surface of target cells, which include a variety of immune cells such as Th2 cells, mast cells, and group 2 innate lymphoid cells (ILC2s). This interaction leads to the activation of signaling pathways that promote the production of Th2-associated cytokines, contributing to the immune response against infections and playing a role in allergic inflammation. Elevated levels of IL-33 have been associated with various inflammatory and autoimmune diseases, including asthma, rheumatoid arthritis, and inflammatory bowel disease (IBD). Due to its significant role in modulating immune responses, pro-IL-33 is a critical target for research aimed at developing new treatments for inflammatory and autoimmune conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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